SynthesisNeuropsychology review2019
Neurobiological and Cognitive Profile of Young Binge Drinkers: a Systematic Review and Meta-Analysis.
Synthesis in Neuropsychology review, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.
- Age-related differences in the effect of chronic alcohol on cognition and the brain: a systematic review.Translational psychiatry · 2022Pooled it
- A Randomized Controlled Trial of N-acetylcysteine for Adolescent and Young Adult Alcohol Use Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Trial
- N-acetylcysteine does not alter neurometabolite levels in non-treatment seeking adolescents who use alcohol heavily: A preliminary randomized clinical trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Trial
- The Role of Anterior Insular Parvalbumin GABAergic Interneurons in Impulsivity-Related and Alcohol-Seeking Behaviors.CNS neuroscience & therapeutics · 2026Article
- Young minds in distress: Exploring the global rise in youth mental health diagnoses.Molecular psychiatry · 2026Review
- Reply: The consequences of MDMA use are not easily disentangled from other drug use or lifestyle factors.Brain : a journal of neurology · 2026Article
- Declining trends in adolescent alcohol consumption and related harms: No room for complacency (an empirical reply to Vieira et al. 2025).Addiction (Abingdon, England) · 2026Article
- Low-Level Alcohol Consumption in Children 11-12 Years Old Is Linked to Neural Substrates Involved in Reward Processing and Inhibitory Control: Results From a Brain-Wide Association Study.Alcohol, clinical & experimental research · 2026Article
- Leveraging bifactor modeling to test prospective direct and indirect effects of adolescent alcohol use and externalizing symptoms on the development of task-general executive functioning.Development and psychopathology · 2025Article
- Article
- Unveiling alcohol bias and impaired inhibitory control in young binge drinkers: insights from the alcohol hayling task.Scientific reports · 2025Article
- Influence of binge drinking on the resting state functional connectivity of university Students: A follow-up study.Addictive behaviors reports · 2025Article
- Higher alcohol use is associated with subsequent increased risk seeking toward gains: A longitudinal cohort study in young men.Alcohol, clinical & experimental research · 2025Article
- Article
- The Continuing Challenges of Studying Parallel Behaviours in Humans and Animal Models.Current topics in behavioral neurosciences · 2025Review
- Associative memory in alcohol-related contexts: An fMRI study with young binge drinkers.Journal of psychopharmacology (Oxford, England) · 2024Article
- Adolescent alcohol consumption predicted by differences in electrophysiological functional connectivity and neuroanatomy.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Associations between Adolescent Alcohol Use and Neurocognitive Functioning in Young Adulthood.Applied developmental science · 2024Article
- The role of impulsivity in the relationship between affect and alcohol consumption in young adults.Alcohol, clinical & experimental research · 2023Article
- Consequences of adolescent drug use.Translational psychiatry · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
This review provides the first systematic and quantitative synthesis of the literature examining the relationship between binge drinking, cognition, brain structure and function in youth aged 10 to 24 years. PubMed, EMBASE, Medline, PsychINFO and ProQuest were searched for neuroimaging, neurophysiological, and neuropsychological studies. A total of 58 studies (21 neuroimaging, 16 neurophysiological, 21 neuropsychological) met the eligibility criteria and were included in the review. Overall, abnormal or delayed development of key frontal executive-control regions may predispose youth to binge drink. These abnormalities appear to be further exacerbated by the uptake of binge drinking, in addition to alcohol-related neural aberrations in reward-seeking and incentive salience regions, indexed by cognitive deficits and maladaptive alcohol associations. A meta-analysis of neuropsychological correlates identified that binge drinking in youth was associated with a small overall neurocognitive deficit (g = -0.26) and specific deficits in decision-making (g = -1.70), and inhibition (g = -0.39). Using the Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) Evidence Profile, the certainty in outcomes ranged from very low to low. Future prospective longitudinal studies should address concomitant factors, exposure thresholds, and age-related vulnerabilities of binge drinking, as well as the degree of recovery following discontinuation of use.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.