ArticleBreast cancer research and treatment2019
The impact of health symptoms on health-related quality of life in early-stage breast cancer survivors.
Article in Breast cancer research and treatment, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 6 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Mental Health Screening Tools for Cancer Patients, and Their Caregivers: An Umbrella Review.Psycho-oncology · 2026Pooled it
- Internet-Based Interventions in Quality of Life Assessments Among Women Living With Breast Cancer: A Systematic and Meta-Analytic Approach.Cancer reports (Hoboken, N.J.) · 2025Pooled it
- Social relationship challenges perceived by cancer patients and survivors: a qualitative meta-synthesis.BMC psychology · 2025Pooled it
- Psychosocial factors associated with quality of life in cancer patients undergoing treatment: an umbrella review.Health and quality of life outcomes · 2025Pooled it
- Evaluating the effect of upper-body morbidity on quality of life following primary breast cancer treatment: a systematic review and meta-analysis.Journal of cancer survivorship : research and practice · 2024Pooled it
- Psychosocial factors associated with quality of life in cancer survivors: umbrella review.Journal of cancer research and clinical oncology · 2024Pooled it
- Effect of early integration of supportive care in addition to standard care in patients with breast cancer: A randomised controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Trial
- Experiences of rehabilitation one year after breast cancer diagnosis-A focus group study from the ReScreen randomized controlled trial.PloS one · 2025Trial
- The 6 month interim analysis of a randomized controlled trial assessing the quality of life in patients with breast cancer related lymphedema undergoing lymphaticovenous anastomosis vs. conservative therapy.Scientific reports · 2024Trial
- Ribociclib plus fulvestrant for advanced breast cancer: Health-related quality-of-life analyses from the MONALEESA-3 study.Breast (Edinburgh, Scotland) · 2020Trial
- Reduced symptom burden with the support of an interactive app during neoadjuvant chemotherapy for breast cancer - A randomized controlled trial.Breast (Edinburgh, Scotland) · 2020Trial
- Catalyzing Navigation for Breast Cancer Survivorship (CaNBCS) in Safety-Net Settings: A Mixed Methods Study.Cancer control : journal of the Moffitt Cancer CenterTrial
- Moving beyond cancer: longitudinal changes in 24-hour movement behaviors and their association with quality of life in breast cancer survivors.Journal of activity, sedentary and sleep behaviors · 2026Article
- One size does not fit all: data-driven insights of patient-reported outcomes to tailor supportive care in breast cancer.Breast cancer research : BCR · 2026Article
- Relationships Between Fear of Cancer Recurrence, Unmet Healthcare Needs, and Quality of Life Among Thai Breast Cancer Survivors Post-Treatment.Healthcare (Basel, Switzerland) · 2026Article
- Article
- Long-term health-related quality of life among adolescent and young adult breast cancer survivors.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Ongoing Symptoms and Concerns Experienced by Low-Risk Breast Cancer Survivors Following Active Treatment.Annals of surgical oncology · 2025Article
- Health-related quality of life in long-term early-stage breast cancer survivors compared to general population in Korea.Journal of cancer survivorship : research and practice · 2025Article
- Development of machine learning models to predict cancer-related fatigue in Dutch breast cancer survivors up to 15 years after diagnosis.Journal of cancer survivorship : research and practice · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
purposeIn breast cancer patients, treatment-related health symptoms can occur that may affect their health-related quality of life (HRQoL). This study aimed to determine the impact of health symptoms on HRQoL in breast cancer patients up to 5 years after diagnosis.
methodsFemales surgically treated for early-stage breast cancer diagnosed between 2012 and 2016 (n = 876) were selected from the Netherlands Cancer Registry and invited for a survey about current health symptoms ('Symptoms and Perceptions questionnaire', SaP) and HRQoL ('EORTC-QLQ-C30'). From the latter, functioning and global health were included. Mean scores were compared to norm population scores (T test). Multivariable linear regression analyses were performed to determine the association between health symptoms and global health and functioning.
results404 patients (46%) responded. The median age was 62.2 ± 10.9 years. Respondents had significantly lower mean scores for role, cognitive, emotional, and social functioning than the general population. The most frequently reported health symptoms were musculoskeletal (including pain/complaints in lower/upper extremities/back/neck; 71%) and central nervous system symptoms (including concentration impairment, dizziness, neuralgia; 66%), and fatigue (63%). While most symptoms affected functioning, irrespective of time since diagnosis, especially fatigue, musculoskeletal, central nervous system, and gastrointestinal symptoms were significantly associated (p < 0.05) with lower functioning.
conclusionsThe majority of health symptoms that occur after breast cancer treatment were associated with lower functioning of patients in daily life. This paper urges healthcare providers to support breast cancer patients in alleviating or coping with health symptoms, even years after end of treatment, to improve their functioning.
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