Evidence map›Paper›PMID 31512042›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2019

Association of HK2 and NCK2 with normal-tension glaucoma in a population from the Republic of Korea.

Seung-Hyun Jung, Young Chun Lee, Mee Yon Lee, Hye-Young Shin

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In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Pooled it
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  3. Review
4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Seung-Hyun JungCancer Evolution Research Center, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Young Chun LeeDepartment of Ophthalmology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 271 Cheonbo-ro, Uijeongbu-si, Gyeonggi-do, 11765, Republic of Korea.
Mee Yon LeeDepartment of Ophthalmology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 271 Cheonbo-ro, Uijeongbu-si, Gyeonggi-do, 11765, Republic of Korea.
Hye-Young ShinDepartment of Ophthalmology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 271 Cheonbo-ro, Uijeongbu-si, Gyeonggi-do, 11765, Republic of Korea. antares78@empal.com.ORCID http://orcid.org/0000-0001-9125-197X
The Catholic University of Korea Uijeongbu St. Mary's Hospital · KRCatholic University of Korea · KR

Funding

Catholic University of Korea Uijeongbu St. Mary's Hospital Clinical Research Laboratory Foundation UJBCRL201823Cheil-Nammyung Foundation Research Funds 2018National Research Foundation of Korea(NRF) grant funded by the Korea government(MSIT) NRF-2018R1D1A1B07047231
6 · The paper itself

Abstract

backgroundPrevious studies have reported the association of HK2 and NCK2 genes with normal-tension glaucoma (NTG) in Japan, but there has been no follow-up study in other countries, so the relevance of these genes to NTG appears uncertain at present. Thus, we investigated the relationship between the HK2 and NCK2 genes and NTG in a Korean NTG cohort.

methodsIn total, 154 unrelated Korean patients with NTG and 101 normal Korean controls were recruited. Thus, a total of 255 participants were analyzed for NCK2 (rs2033008) and HK2 (rs678350) gene polymorphisms.

resultsThe minor allele frequency (MAF) of rs678350 was significantly higher in NTG patients (MAF = 0.32) than in controls (MAF = 0.23) (OR, 1.586; 95% CI, 1.058 to 2.375; P = 0.028). This trend was more significant in the dominant model (OR, 1.908; 95% CI, 1.144 to 3.180; P = 0.015). When we performed logistic regression analysis to adjust for age, both the allelic and dominant models were still statistically significant. No significant difference was observed in rs2033008 allele or genotype frequencies between the NTG patients and control subjects.

conclusionsThe current study suggested that HK2 gene polymorphism may contribute to the genetic susceptibility to NTG.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAdaptor Proteins, Signal TransducingAgedAllelesDNAFemaleGene FrequencyGenotypeHexokinaseHumansIncidenceIntraocular PressureLow Tension GlaucomaMaleMiddle AgedAdaptor Proteins, Signal TransducingDNAHexokinaseHK2 protein, humanNCK2 protein, humanOncogene ProteinsGenotypingHexokinase 2Non-catalytic region of tyrosine kinase adaptor protein 2Normal-tension glaucomaSingle nucleotide polymorphismSouth Korea

Identifiers

PMID31512042
OpenAlexW2972747193

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.