Evidence map›Paper›PMID 31512009›Full record

ArticleIntensive care medicine experimental2019

Peroxynitrite decomposition catalyst reduces vasopressin requirement in ovine MRSA sepsis.

Osamu Fujiwara, Satoshi Fukuda, Ernesto Lopez, Yaping Zeng, Yosuke Niimi, Douglas S DeWitt, David N Herndon, Donald S Prough, Perenlei Enkhbaatar

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Intensive care medicine experimental, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Osamu FujiwaraDepartment of Anesthesiology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, 77555 1102, USA.
Satoshi FukudaDepartment of Anesthesiology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, 77555 1102, USA.
Ernesto LopezDepartment of Anesthesiology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, 77555 1102, USA.
Yaping ZengDepartment of Anesthesiology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, 77555 1102, USA.
Yosuke NiimiDepartment of Anesthesiology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, 77555 1102, USA.
Douglas S DeWittDepartment of Anesthesiology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, 77555 1102, USA.
David N HerndonShriners Hospital for Children, Galveston, Texas, USA.
Donald S ProughDepartment of Anesthesiology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, 77555 1102, USA.
Perenlei EnkhbaatarDepartment of Anesthesiology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, 77555 1102, USA. peenkhba@utmb.edu.
The University of Texas Medical Branch at Galveston · USShriners Hospitals for Children - Galveston · US

Funding

Etiology of Microvascular Changes in Gram-positive Sepsis: Mechanisms and Therapeutic OptionsR01GM097480 · NIGMS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI ENKHBAATAR, PERENLEI · 2012 to 2022
$2.7M
NIGMS NIH HHS GM097480NIGMS NIH HHS R01 GM097480Shriners Hospitals for Children SHC84050, SHC85100
6 · The paper itself

Abstract

backgroundSepsis is one of the most frequent causes of death in the intensive care unit. Host vascular hypo-responsiveness to vasopressors during septic shock is one of the challenging problems. This study tested the hypothesis that adjunct therapy with peroxynitrite decomposition catalyst (WW-85) would reduce arginine vasopressin (AVP) requirements during sepsis resuscitation, using ovine sepsis model.

methodsThirteen adult female Merino sheep, previously instrumented with multiple vascular catheters, were subjected to "two-hit" (cotton smoke inhalation and intrapulmonary instillation of live methicillin-resistant Staphylococcus aureus; 3.5 × 10

resultsThe injury induced severe hypotension refractory to aggressive fluid resuscitation. High doses of AVP were required to partially attenuate the sepsis-induced hypotension. However, the cumulative AVP requirement was significantly reduced by adjunct treatment with WW-85 at 17-24 h after the injury (p < 0.05). Total AVP dose and the highest AVP rate were significantly lower in the WW-85 + AVP group compared to the AVP group (p = 0.02 and 0.04, respectively). Treatment with WW-85 had no adverse effects. In addition, the in vitro effects of AVP on isolated artery diameter changes were abolished with peroxynitrite co-incubation.

conclusionsThe modulation of reactive nitrogen species, such as peroxynitrite, may be considered as a novel adjunct treatment option for septic shock associated with vascular hypo-responsiveness to vasopressors.

Indexed as

Arginine vasopressinPeroxynitrite decomposition catalystRefractory shockSeptic shockVascular hypo-responsivenessWW-85

Identifiers

PMID31512009
PMCPMC6738358
OpenAlexW2972693539

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.