Evidence map›Paper›PMID 31512003›Full record

ArticleAnnals of intensive care2019

Association of endothelial and glycocalyx injury biomarkers with fluid administration, development of acute kidney injury, and 90-day mortality: data from the FINNAKI observational study.

Nina Inkinen, Ville Pettilä, Päivi Lakkisto, Anne Kuitunen, Sakari Jukarainen, Stepani Bendel, Outi Inkinen, Tero Ala-Kokko, Suvi T Vaara, FINNAKI Study Group

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PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of intensive care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 87 citations in OpenAlex.

  1. Pooled it
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  4. [Sepsis-induced coagulopathy].Die Anaesthesiologie · 2026
    Review
  5. Endothelial Exostosin-1 Is Needed for Glycocalyx Integrity and Inflammatory Resolution in Acute Lung Injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Nina InkinenDepartment of Anesthesia and Intensive Care, Central Finland Central Hospital, Central Finland Health Care District, Keskussairaalantie 19 M rak 2krs, 40620, Jyväskylä, Finland. nina.inkinen@ksshp.fi.ORCID http://orcid.org/0000-0002-2551-9322
Ville PettiläDivision of Intensive Care Medicine, Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Päivi LakkistoDepartment of Clinical Chemistry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Anne KuitunenDepartment of Intensive Care, University of Tampere and Tampere University Hospital, Tampere, Finland.
Sakari JukarainenDivision of Intensive Care Medicine, Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Stepani BendelDepartment on Intensive Care Medicine, Kuopio University Hospital, Kuopio, Finland.
Outi InkinenDepartment of Anaesthesia and Intensive Care Medicine, Turku University Hospital, Turku, Finland.
Tero Ala-KokkoResearch Group of Surgery, Anesthesiology and Intensive Care Medicine and Medical Research Center, Oulu University Hospital, Oulu University, Oulu, Finland.
Suvi T VaaraDivision of Intensive Care Medicine, Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
FINNAKI Study Group
University of Helsinki · FIOulu University Hospital · FICentral Finland Health Care District · FITurku University Hospital · FI

Funding

Academy of Finland 317061Institutional grants from Helsinki University Hospital TYH2013343Institutional grants from Helsinki University Hospital TYH2016243Institutional grants from Helsinki University Hospital TYH2017241
6 · The paper itself

Abstract

backgroundInjury to endothelium and glycocalyx predisposes to vascular leak, which may subsequently lead to increased fluid requirements and worse outcomes. In this post hoc study of the prospective multicenter observational Finnish Acute Kidney Injury (FINNAKI) cohort study conducted in 17 Finnish intensive care units, we studied the association of Syndecan-1 (SDC-1), Angiopoetin-2 (Ang-2), soluble thrombomodulin (sTM), vascular adhesion protein-1 (VAP-1) and interleukin-6 (IL-6) with fluid administration and balance among septic critical care patients and their association with development of acute kidney injury (AKI) and 90-day mortality.

resultsSDC-1, Ang-2, sTM, VAP-1 and IL-6 levels were measured at ICU admission from 619 patients with sepsis. VAP-1 decreased (p < 0.001) and IL-6 increased (p < 0.001) with increasing amounts of administered fluid, but other biomarkers did not show differences according to fluid administration. In linear regression models adjusted for IL-6, only VAP-1 was significantly associated with fluid administration on day 1 (p < 0.001) and the cumulative fluid balance on day 5/ICU discharge (p = 0.001). Of 415 patients admitted without AKI, altogether 112 patients (27.0%) developed AKI > 12 h from ICU admission (AKI

conclusionsVAP-1 and IL-6 associated with fluid administration on the first ICU day. After adjusting for confounders, sTM was associated with development of AKI after 12 h from ICU admission. SDC-1, Ang-2 and sTM were independently associated with an increased risk for 90-day mortality.

Indexed as

Acute kidney injuryBiomarkerFluid balanceFluid resuscitationGlycocalyxSepsisSoluble thrombomodulin

Identifiers

PMID31512003
PMCPMC6738365
OpenAlexW2972982405

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.