ArticleNaunyn-Schmiedeberg's archives of pharmacology2020
Normalization of organ bath contraction data for tissue specimen size: does one approach fit all?
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The trial behind it
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Who cites it
14 citing papers in PubMed.
- Disease exacerbation in human DMD MYOrganoids enables gene therapy evaluation and unveils persistence of fibrotic activity.NPJ Regenerative medicine · 2026Article
- Effect of taurine on vascular dysfunction in an in vitro ischemia-reperfusion model of rat thoracic aorta.General thoracic and cardiovascular surgery · 2025Article
- Intracellular signaling pathways of muscarinic acetylcholine receptor-mediated detrusor muscle contractions.American journal of physiology. Renal physiology · 2023Article
- The role of intracellular calcium and Rho kinase pathways in G protein-coupled receptor-mediated contractions of urinary bladder urothelium and lamina propria.American journal of physiology. Cell physiology · 2023Article
- Dog and human bladders have different neurogenic and nicotinic responses in inner versus outer detrusor muscle layers.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- A Potential Role of Cholinergic Dysfunction on Impaired Colon Motility in Experimental Intestinal Chagas Disease.Journal of neurogastroenterology and motility · 2022Article
- Review
- Inhibition of neurogenic contractions in renal arteries and of cholinergic contractions in coronary arteries by the presumed inhibitor of ADP-ribosylation factor 6, NAV2729.Naunyn-Schmiedeberg's archives of pharmacology · 2022Article
- Inhibition of Human Prostate and Bladder Smooth Muscle Contraction, Vasoconstriction of Porcine Renal and Coronary Arteries, and Growth-Related Functions of Prostate Stromal Cells by Presumed Small Molecule GαFrontiers in physiology · 2022Article
- Purinergic smooth muscle contractions in the human prostate: estimation of relevance and characterization of different agonists.Naunyn-Schmiedeberg's archives of pharmacology · 2021Article
- Picotamide inhibits a wide spectrum of agonist-induced smooth muscle contractions in porcine renal interlobar and coronary arteries.Pharmacology research & perspectives · 2021Article
- Oxytocin receptor antagonists as a novel pharmacological agent for reducing smooth muscle tone in the human prostate.Scientific reports · 2021Article
- Concentration-dependent alphaFrontiers in pharmacology · 2021Article
- Choice of y-axis can mislead readers.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Organ bath experiments are a key technology to assess contractility of smooth muscle. Despite efforts to standardize tissue specimen sizes, they vary to a certain degree. As it appears obvious that a larger piece of tissue should develop greater force, most investigators normalize contraction data for specimen size. However, they lack agreement which parameter should be used as denominator for normalization. A pre-planned analysis of data from a recent study was used to compare denominators used for normalization, i.e., weight, length, and cross-sectional area. To increase robustness, we compared force with denominator in correlation analysis and also coefficient of variation with different denominators. This was done concomitantly with urinary bladder strips and aortic rings and with multiple contractile stimuli. Our urinary bladder data show that normalization for strip weight yielded the tightest but still only moderate correlation (e.g., r
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.