Observational studyThe Journal of clinical endocrinology and metabolism2020
Differential Resting State Connectivity Responses to Glycemic State in Type 1 Diabetes.
Observational study in The Journal of clinical endocrinology and metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed, 28 citations in OpenAlex.
- Cognitive flexibility is associated with the age of onset and duration among patients with type 1 diabetes.Scientific reports · 2025Article
- Type-1 Diabetes Impacts Brain Microstructure and Anatomical Associations in Young and Well-Controlled Individuals.Brain topography · 2025Article
- Low-calorie diet-induced weight loss is associated with altered brain connectivity and food desire in obesity.Obesity (Silver Spring, Md.) · 2024Article
- Alterations in intra- and inter-network connectivity associated with cognition impairment in insulinoma patients.Frontiers in endocrinology · 2023Article
- Altered functional connectivity during hypoglycaemia in type 1 diabetes.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
contextIndividuals with type 1 diabetes mellitus (T1DM) have alterations in brain activity that have been postulated to contribute to the adverse neurocognitive consequences of T1DM; however, the impact of T1DM and hypoglycemic unawareness on the brain's resting state activity remains unclear.
objectiveTo determine whether individuals with T1DM and hypoglycemia unawareness (T1DM-Unaware) had changes in the brain resting state functional connectivity compared to healthy controls (HC) and those with T1DM and hypoglycemia awareness (T1DM-Aware).
designObservational study.
settingAcademic medical center.
participants27 individuals with T1DM and 12 HC volunteers participated in the study.
interventionAll participants underwent blood oxygenation level dependent (BOLD) resting state functional magnetic brain imaging during a 2-step hyperinsulinemic euglycemic (90 mg/dL)-hypoglycemic (60 mg/dL) clamp. OUTCOME: Changes in resting state functional connectivity.
resultsUsing 2 separate methods of functional connectivity analysis, we identified distinct differences in the resting state brain responses to mild hypoglycemia between HC, T1DM-Aware, and T1DM-Unaware participants, particularly in the angular gyrus, an integral component of the default mode network (DMN). Furthermore, changes in angular gyrus connectivity also correlated with greater symptoms of hypoglycemia (r = 0.461, P = 0.003) as well as higher scores of perceived stress (r = 0.531, P = 0.016).
conclusionThese findings provide evidence that individuals with T1DM have changes in the brain's resting state connectivity patterns, which may be further associated with differences in awareness to hypoglycemia. These changes in connectivity may be associated with alterations in functional outcomes among individuals with T1DM.
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