Evidence map›Paper›PMID 31511699›Full record

ArticleNature2019

Genome architecture and stability in the Saccharomyces cerevisiae knockout collection.

Fabio Puddu, Mareike Herzog, Alexandra Selivanova, Siyue Wang, Jin Zhu, Shir Klein-Lavi, Molly Gordon, Roi Meirman, Gonzalo Millan-Zambrano, Iñigo Ayestaran and 5 more

Abstract read
In one paragraph

Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed.

  1. Review
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  13. Flow-cytometry reveals mitochondrial DNA accumulation inFrontiers in cell and developmental biology · 2024
    Article
  14. Spontaneous Mutations inInternational journal of molecular sciences · 2023
    Article
  15. Article
  16. Article
  17. Mining theJournal of fungi (Basel, Switzerland) · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Fabio PudduThe Wellcome Trust/CRUK Gurdon Institute, University of Cambridge, Cambridge, UK. f.puddu@gurdon.cam.ac.uk.
Mareike HerzogThe Wellcome Trust/CRUK Gurdon Institute, University of Cambridge, Cambridge, UK.
Alexandra SelivanovaThe Wellcome Trust/CRUK Gurdon Institute, University of Cambridge, Cambridge, UK.
Siyue WangThe Wellcome Trust/CRUK Gurdon Institute, University of Cambridge, Cambridge, UK.
Jin ZhuCenter for Cell Dynamics, Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Shir Klein-LaviSchool of Molecular Cell Biology and Biotechnology, Tel Aviv University, Tel Aviv, Israel.
Molly GordonCenter for Cell Dynamics, Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Roi MeirmanSchool of Molecular Cell Biology and Biotechnology, Tel Aviv University, Tel Aviv, Israel.
Gonzalo Millan-ZambranoThe Wellcome Trust/CRUK Gurdon Institute, University of Cambridge, Cambridge, UK.
Iñigo AyestaranThe Wellcome Trust/CRUK Gurdon Institute, University of Cambridge, Cambridge, UK.
Israel SalgueroThe Wellcome Trust/CRUK Gurdon Institute, University of Cambridge, Cambridge, UK.
Roded SharanSchool of Computer Science, Tel Aviv University, Tel Aviv, Israel.
Rong LiCenter for Cell Dynamics, Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Martin KupiecSchool of Molecular Cell Biology and Biotechnology, Tel Aviv University, Tel Aviv, Israel.
Stephen P JacksonThe Wellcome Trust/CRUK Gurdon Institute, University of Cambridge, Cambridge, UK. s.jackson@gurdon.cam.ac.uk.

Funding

BIOCHEMISTRY, CELLULAR AND MOLECULAR BIOLOGY PROGRAMT32GM007445 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 1985 to 2021
$24.1M
Cellular dynamics in division, motility and evolutionary adaptationR35GM118172 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI LI, RONG · 2016 to 2019
$2.8M
Cancer Research UK 18796Cancer Research UK A18796Cancer Research UK A24843NIGMS NIH HHS R35 GM118172NIGMS NIH HHS T32 GM007445Wellcome Trust 098051Wellcome Trust 101126Wellcome Trust 203144Wellcome Trust 206388Wellcome Trust 206388/Z/17/Z
6 · The paper itself

Abstract

Despite major progress in defining the functional roles of genes, a complete understanding of their influences is far from being realized, even in relatively simple organisms. A major milestone in this direction arose via the completion of the yeast Saccharomyces cerevisiae gene-knockout collection (YKOC), which has enabled high-throughput reverse genetics, phenotypic screenings and analyses of synthetic-genetic interactions

Indexed as

Genomic InstabilityAdaptation, BiologicalGene Knockout TechniquesGenome, FungalGenome, MitochondrialSaccharomyces cerevisiaeWhole Genome Sequencing

Identifiers

PMID31511699
PMCPMC6774800

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.