ArticleNature2019
DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome.
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Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 253 papers.
0numbers the graph read from it
0cells of the map it votes in
253citing papers in PubMed
14.7field-weighted citation impact, top 1% of its field
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Who cites it
253 citing papers in PubMed, 414 citations in OpenAlex.
- E3 ubiquitin ligase SYVN1 mediates K63-linked ubiquitination of DDX3X to activate Macrophage NLRP3 Inflammasome.bioRxiv : the preprint server for biology · 2026Article
- DDX3X overexpression in mice can cause rapid tissue-specific toxicity and mortality.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- TRIM21 blocks DDX3X-driven stress granule formation during Mycobacterium tuberculosis infection via a non-canonical E3 ligase mechanism.PLoS pathogens · 2026Article
- Characterizing the molecular mechanisms underlying aluminium-induced disruptions in neuronal survival pathways.Metabolic brain disease · 2026Review
- DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated-Acute Kidney Injury.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Delaying Stress Granule Disassembly by PARG Inhibition Attenuates Renal Tubular Cell Pyroptosis in Acute Kidney Injury.International journal of molecular sciences · 2026Article
- Stress granule dynamics orchestrate colitis-to-cancer transition via TOM1-mediated disassembly and driven oncogenesis in response to inflammatory oxidative stress.Redox biology · 2026Article
- Nrf2 promotes NLRP3 inflammasome assembly and activation by Klf9-TXNIP axis.Cell death discovery · 2026Article
- Comprehensive analysis of the RBP regulome reveals functional modules and drug candidates in liver cancer.Scientific reports · 2026Article
- RNA helicase DDX6 governs ASC speck formation in P-bodies and the transition to stress granules via phase separation during inflammasome activation.Cell discovery · 2026Article
- Liquid-liquid phase separation-driven regulated cell death: from molecular mechanisms to therapeutic strategies.Cell death discovery · 2026Review
- Targeting the DDX3/PAF1 axis enhances chemotherapy efficacy in pancreatic ductal adenocarcinoma.Cancer letters · 2026Article
- Stress Granule Sequestration of CCR4-NOT Promotes Poly(A) Lengthening of Stress-Survival Transcripts.bioRxiv : the preprint server for biology · 2026Article
- RK-33 inhibits the OC43 coronavirus and induces stress granules via DDX3X-independent mechanisms.RNA (New York, N.Y.) · 2026Article
- Substantially Altered Local and Systemic Immunity in Ischemia-Free Versus Conventional Liver Transplantation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- CRISPR/Cas9 knockout of DDX5 facilitates foot-and-mouth disease virus replication in PK-15 cells.Archives of virology · 2026Article
- Diverse Scaffolds Facilitate NLRP3 Clustering and Inflammasome Formation in Response to Perturbations in Cell Homeostasis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Implications of virus-induced stress granules in tauopathies.Translational neurodegeneration · 2026Review
- Enhancing Mitophagy with PEP-1-CAT Attenuates Vascular Inflammation and Atherogenesis in Mice.Inflammation · 2026Article
- African swine fever virus pEP364R acts as an important inflammatory-inducing factor to activate NLRP3 inflammasome-mediated pyroptosis by regulating DDX3X.PLoS pathogens · 2026Article
193 more citing papers are in PubMed but not listed here.
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Authors and funding
18 authors at 3 institutions in 2 countries.
Parimal Samir *Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Sannula Kesavardhana *Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Deanna M Patmore *Cancer Research UK Cambridge Institute, Li Ka Shing Centre, Cambridge, UK.
Sebastien GingrasDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
R K Subbarao MalireddiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Rajendra KarkiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Clifford S GuyDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Benoit BriardDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
David E PlaceDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Anannya BhattacharyaDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Bhesh Raj SharmaDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Amanda NourseThe Molecular Interaction Shared Resource, St. Jude Children's Research Hospital, Memphis, TN, USA.
Sharon V KingCell and Tissue Imaging Center, Light Microscopy Division, St. Jude Children's Research Hospital, Memphis, TN, USA.
Aaron PitreCell and Tissue Imaging Center, Light Microscopy Division, St. Jude Children's Research Hospital, Memphis, TN, USA.
Amanda R BurtonDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Stephane PelletierDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Richard J GilbertsonCancer Research UK Cambridge Institute, Li Ka Shing Centre, Cambridge, UK. richard.gilbertson@cruk.cam.ac.uk.
Thirumala-Devi KannegantiDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA. Thirumala-Devi.Kanneganti@stjude.org.
St. Jude Children's Research Hospital · USCancer Research UK Cambridge Center · GBUniversity of Pittsburgh · US
Funding
Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CHARLES ROBERTS · 1985 to 2026
$166.9MThe DNA Damage Response and Tumorigenesis in the BrainP01CA096832 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI BAKER, SUZANNE J. · 2003 to 2025
$38.0MRole of NLR Inflammasomes in Autoinflammatory Diseases and Host DefenseR01AR056296 · NIAMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI KANNEGANTI, THIRUMALA-DEVI · 2008 to 2022
$5.9MThe Non-Inflammasome NLRs in Immunity and Host defenseR01AI124346 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Thirumala-Devi Kanneganti · 2016 to 2026
$5.8MInflammatory Caspases in Innate Immunity and InflammationR37AI101935 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Thirumala-Devi Kanneganti · 2017 to 2026
$4.9MNLR signaling in colitis and colorectal tumorigenesisR01CA163507 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI KANNEGANTI, THIRUMALA-DEVI · 2012 to 2020
$3.5MInflammatory Caspases in Innate Immunity and InflammationR01AI101935 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI KANNEGANTI, THIRUMALA-DEVI · 2012 to 2016
$2.2MCancer Research UK 22492NCI NIH HHS P01 CA096832NCI NIH HHS P30 CA021765NCI NIH HHS P30 CA021765-35NCI NIH HHS R01 CA163507NIAID NIH HHS R01 AI101935NIAID NIH HHS R01 AI124346NIAID NIH HHS R37 AI101935NIAMS NIH HHS R01 AR056296NIH HHS AI101935NIH HHS AI124346NIH HHS AR056296NIH HHS CA163507NIH HHS R0CA1129541
Abstract
The cellular stress response has a vital role in regulating homeostasis by modulating cell survival and death. Stress granules are cytoplasmic compartments that enable cells to survive various stressors. Defects in the assembly and disassembly of stress granules are linked to neurodegenerative diseases, aberrant antiviral responses and cancer
Indexed as
AnimalsCell DeathCell LineCell SurvivalDEAD-box RNA HelicasesGene Expression ProfilingGene Expression Regulation, DevelopmentalHEK293 CellsHumansInflammasomesMacrophagesMiceNLR Family, Pyrin Domain-Containing 3 ProteinStress, PhysiologicalDdx3x protein, mouseDEAD-box RNA HelicasesInflammasomesNLR Family, Pyrin Domain-Containing 3 Protein
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