ArticleNature2019
SLC19A1 transports immunoreactive cyclic dinucleotides.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 227 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
227citing papers in PubMed, 1 pooled it
16.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
227 citing papers in PubMed, 1 synthesis or guideline pooled it, 379 citations in OpenAlex.
- Bacteria-based immunotherapy for cancer: a systematic review of preclinical studies.Frontiers in immunology · 2023Pooled it
- The cGAS-STING pathway in inflammaging and neuroinflammation.Science China. Life sciences · 2026Review
- The SLC-ome of membrane transport: from molecular discovery to physiology and clinical applications.Physiological reviews · 2026Review
- Mitochondrial Fis1 tunes Rab7A activity via TBC1D15 modulating STING degradation.Cell reports · 2026Article
- STING agonist profiling by nucleotide library defines structural determinants of cyclic dinucleotide recognition.iScience · 2026Article
- Purine and pyrimidine-based bacterial cyclic dinucleotides egress the phagosome and activate the innate immune sensor STING.Immunity · 2026Article
- The cGAS/STING pathway in cancer: translating innate DNA sensing into therapeutic potential.The Journal of clinical investigation · 2026Review
- Review
- MTHFR C677T genetic polymorphisms are not a decisive factor in delayed methotrexate excretion in central nervous system lymphoma patients.Annals of hematology · 2026Article
- Enhancement of a STING Agonist Vaccine for Tuberculosis Using Locally Supercharged MS2 Viral Capsids.bioRxiv : the preprint server for biology · 2026Article
- The mutational landscape of STING-induced immunity.Nature · 2026Article
- Viral capsid delivery of cGAMP enhances STING-dependent antitumor immune response.bioRxiv : the preprint server for biology · 2026Article
- Molecular mechanisms regulating cGAS/STING activation in health and disease.The Journal of clinical investigation · 2026Review
- Folate receptor beta drives NLRP3 inflammasome activation and pyroptosis in macrophages independent of folate binding.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Bacterial 2',3'-cGAMP activates a SAVED effector to form membrane-disrupting filaments and restrict phage replication.Cell host & microbe · 2026Article
- Calibrating the RT-cGAS-STING axis to drive cold-to-hot tumor transformation: mechanistic foundations and translational strategies for combination with immunotherapy.Molecular cancer · 2026Review
- Precision targeting of STING: Challenges, innovations, and clinical outlook for cancer therapy.Innovation (Cambridge (Mass.)) · 2026Review
- Manipulation of the nucleotide pool in human, bacterial and plant immunity.Nature reviews. Immunology · 2026Review
- Article
- LC3-dependent intercellular transfer of phosphorylated STAT1/2 elicits CXCL9+ macrophages and enhances radiation-induced antitumor immunity.The Journal of clinical investigation · 2025Article
167 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 5 institutions in 2 countries.
Rutger D LuteijnDepartment of Molecular and Cell Biology, and Cancer Research Laboratory, Division of Immunology and Pathogenesis, University of California, Berkeley, CA, USA.
Shivam A ZaverDepartment of Microbiology, University of Washington, Seattle, WA, USA.
Benjamin G GowenInnovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.
Stacia K WymanInnovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.
Nick E GarelisDepartment of Molecular and Cell Biology, and Cancer Research Laboratory, Division of Immunology and Pathogenesis, University of California, Berkeley, CA, USA.
Liberty OniaDepartment of Molecular and Cell Biology, and Cancer Research Laboratory, Division of Immunology and Pathogenesis, University of California, Berkeley, CA, USA.
Sarah M McWhirterAduro Biotech, Berkeley, CA, USA.
George E KatibahAduro Biotech, Berkeley, CA, USA.
Jacob E CornInnovative Genomics Institute, University of California, Berkeley, Berkeley, CA, USA.
Joshua J WoodwardDepartment of Microbiology, University of Washington, Seattle, WA, USA.
David H RauletDepartment of Molecular and Cell Biology, and Cancer Research Laboratory, Division of Immunology and Pathogenesis, University of California, Berkeley, CA, USA. raulet@berkeley.edu.
University of California, Berkeley · USAduro BioTech (United States) · USUniversity of Washington · USETH Zurich · CHInnovative Genomics Institute · US
Funding
University of Washington Medical Scientist Training Program: MD/PhDT32GM007266 · NIGMS · UNIVERSITY OF WASHINGTON · PI HORWITZ, MARSHALL S. · 1985 to 2023
$30.4MRole of NKG2D in immune responses to turmorsR01CA093678 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI RAULET, DAVID H · 2003 to 2019
$4.2MSTING-dependent activation of Natural Killer cells by viral and tumor DNAR01AI113041 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI RAULET, DAVID H · 2014 to 2024
$4.1MViral Pathogenesis Training ProgramT32AI083203 · NIAID · UNIVERSITY OF WASHINGTON · PI BLOOM, JESSE D, LAGUNOFF, MICHAEL · 2009 to 2023
$2.7MDiscovering mechanisms that regulate organelle autophagyDP2HL141006 · NHLBI · UNIVERSITY OF CALIFORNIA BERKELEY · PI CORN, JACOB ELLERY · 2017 to 2017
$2.4MGenome Sequencer FLXS10RR029668 · NCRR · UNIVERSITY OF CALIFORNIA BERKELEY · PI NGAI, JOHN J. · 2010 to 2010
$623kPacific Biosciences PacBio RS Single Molecule Real Time SequencerS10OD018174 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI ROKHSAR, DANIEL SOLEYMAN · 2014 to 2014
$600kIllumina Sequencer to Facilitate Functional Genomics at BerkeleyS10RR027303 · NCRR · UNIVERSITY OF CALIFORNIA BERKELEY · PI TAYLOR, JOHN W. · 2010 to 2010
$500kSignal transduction of cGAMP during innate immune responsesR21AI137758 · NIAID · UNIVERSITY OF WASHINGTON · PI WOODWARD, JOSHUA · 2018 to 2019
$429kSTING-dependent activation of Natural Killer cells by viral and tumor DNAR56AI113041 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI RAULET, DAVID H · 2019 to 2019
$334kNCI NIH HHS R01 CA093678NCRR NIH HHS S10 RR027303NCRR NIH HHS S10 RR029668NHLBI NIH HHS DP2 HL141006NIAID NIH HHS R01 AI113041NIAID NIH HHS R21 AI137758NIAID NIH HHS R56 AI113041NIAID NIH HHS T32 AI083203NIGMS NIH HHS T32 GM007266NIH HHS S10 OD018174
Abstract
The accumulation of DNA in the cytosol serves as a key immunostimulatory signal associated with infections, cancer and genomic damage
Indexed as
AnimalsCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseCytosolDNAHumansInflammationInterferon Regulatory Factor-3Nucleotides, CyclicNucleotidyltransferasesReduced Folate Carrier ProteincGAS protein, humancyclic guanosine monophosphate-adenosine monophosphateCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDNAInterferon Regulatory Factor-3IRF3 protein, humanNucleotides, CyclicNucleotidyltransferasesReduced Folate Carrier ProteinSLC19A1 protein, human
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.