Evidence map›Paper›PMID 31511635›Full record

ArticleMolecular psychiatry2020

Pianp deficiency links GABA

Manuel Winkler, Siladitta Biswas, Stefan M Berger, Moritz Küchler, Laurens Preisendörfer, Myeongjeong Choo, Simon Früh, Pascal D Rem, Thomas Enkel, Bernd Arnold and 7 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Genetic implication of GABAFrontiers in pharmacology · 2025
    Review
  5. Article
  6. Keeping the Balance: GABABrain sciences · 2022
    Review
  7. Social Deficits and Cerebellar Degeneration in Purkinje CellFrontiers in molecular neuroscience · 2022
    Article
  8. Review
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 2 countries.

Manuel Winkler *Department of Dermatology, Venereology, and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology, Mannheim, Germany.ORCID http://orcid.org/0000-0003-2415-9350
Siladitta Biswas *Department of Dermatology, Venereology, and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology, Mannheim, Germany.
Stefan M BergerDepartment of Molecular Biology, Central Institute of Mental Health and Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Moritz KüchlerInstitute of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany.
Laurens PreisendörferInstitute of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany.
Myeongjeong ChooDepartment of Biomedicine, Institute of Physiology, University of Basel, Basel, Switzerland.
Simon FrühDepartment of Biomedicine, Institute of Physiology, University of Basel, Basel, Switzerland.
Pascal D RemDepartment of Biomedicine, Institute of Physiology, University of Basel, Basel, Switzerland.
Thomas EnkelDepartment of Molecular Biology, Central Institute of Mental Health and Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Bernd ArnoldDivision of Molecular Immunology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Dorde KomljenovicDivision of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Carsten StichtCenter for Medical Research, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Sergij GoerdtDepartment of Dermatology, Venereology, and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology, Mannheim, Germany.
Bernhard BettlerDepartment of Biomedicine, Institute of Physiology, University of Basel, Basel, Switzerland.
Oliver von Bohlen Und HalbachInstitute of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-2613-2517
Dusan BartschDepartment of Molecular Biology, Central Institute of Mental Health and Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Cyrill GéraudDepartment of Dermatology, Venereology, and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, and Center of Excellence in Dermatology, Mannheim, Germany. cyrill.geraud@umm.de.
Heidelberg University · DEUniversity of Basel · CHUniversitätsmedizin Greifswald · DEGerman Cancer Research Center · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pianp (also known as Leda-1) is a type I transmembrane protein with preferential expression in the mammalian CNS. Its processing is characterized by proteolytic cleavage by a range of proteases including Adam10, Adam17, MMPs, and the γ-secretase complex. Pianp can interact with Pilrα and the GB1a subunit of the GABA

Indexed as

Gene DeletionAnimalsAutism Spectrum DisorderAutistic DisorderCerebellumDisease Models, AnimalFemaleHippocampusMaleMiceMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsReceptors, GABA-BNerve Tissue ProteinsPianp protein, mouseReceptors, GABA-B

Identifiers

PMID31511635
PMCPMC7577901
OpenAlexW2972485835

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.