Evidence map›Paper›PMID 31511603›Full record

ArticleScientific reports2019

Evaluation of (-)-epicatechin metabolites as recovery biomarker of dietary flavan-3-ol intake.

Javier I Ottaviani, Reedmond Fong, Jennifer Kimball, Jodi L Ensunsa, Nicola Gray, Anna Vogiatzoglou, Abigail Britten, Debora Lucarelli, Robert Luben, Philip B Grace and 9 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06086145 (Flavanol Intake in Davis), which is not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06086145 active not recruitingnot on this mapstarted 2023, after this paper: background citation

Flavanol Intake in Davis (FID) Study: Biomarker-estimated Habitual (-)-Epicatechin and Flavanol Intake in Adults

TypeobservationalSponsorUniversity of California, DavisRan2023 to 2026Enrolled200ConditionsHealthy, Diet, AdultsArmsNo intervention
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 35 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 2 countries.

Javier I OttavianiMars, Inc., McLean, VA, USA.
Reedmond FongDepartment of Nutrition, UC Davis, Davis, CA, USA.
Jennifer KimballDepartment of Nutrition, UC Davis, Davis, CA, USA.
Jodi L EnsunsaDepartment of Nutrition, UC Davis, Davis, CA, USA.
Nicola GrayDepartment of Food and Nutritional Sciences, University of Reading, Reading, UK.
Anna VogiatzoglouSchool of Life Sciences, Coventry University, Coventry, UK.
Abigail BrittenMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Debora LucarelliMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Robert LubenDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-5088-6343
Philip B GraceLGC, Newmarket Road, Fordham, UK.
Deborah H MawsonLGC, Newmarket Road, Fordham, UK.
Amy TymLGC, Newmarket Road, Fordham, UK.
Antonia WierzbickiLGC, Newmarket Road, Fordham, UK.
A David SmithOPTIMA Department of Pharmacology, University of Oxford, Oxford, UK.
Nicholas J WarehamMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Nita G ForouhiMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-5041-248X
Kay-Tee KhawDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Hagen SchroeterMars, Inc., McLean, VA, USA.
Gunter G C KuhnleDepartment of Food and Nutritional Sciences, University of Reading, Reading, UK. g.g.kuhnle@reading.ac.uk.ORCID http://orcid.org/0000-0002-8081-8931
University of Cambridge · GBUniversity of California, Davis · USMars (United States) · USCoventry University · GBUniversity of Oxford · GBUniversity of Reading · GB

Funding

Cancer Research UK 14136Department of Health IS-BRC-1215-20014Medical Research Council G0401527Medical Research Council G1000143Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12015/5Medical Research Council MR/N003284/1
6 · The paper itself

Abstract

Data from dietary intervention studies suggest that intake of (-)-epicatechin mediates beneficial vascular effects in humans. However, population-based investigations are required to evaluate associations between habitual intake and health and these studies rely on accurate estimates of intake, which nutritional biomarkers can provide. Here, we evaluate a series of structurally related (-)-epicatechin metabolites (SREM), particularly (-)-epicatechin-3'-glucuronide, (-)-epicatechin-3'-sulfate and 3'-O-methyl-(-)-epicatechin-5-sulfate (SREM

Indexed as

DietAdultBiomarkersCatechinCohort StudiesFemaleFlavonoidsHealthy VolunteersHumansMaleMiddle AgedBiomarkersCatechinflavan-3-olFlavonoids

Identifiers

PMID31511603
PMCPMC6739331
OpenAlexW2972117501

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.