ArticleScientific reports2019
Metabolomics Deciphered Metabolic Reprogramming Required for Biofilm Formation.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 59 citations in OpenAlex.
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- Genetic Drivers of Plant Root Colonisation by the Biocontrol Agent Pseudomonas protegens Pf-5.Environmental microbiology reports · 2025Article
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- MUC5B modulation of early oral biofilm glucose metabolism.Frontiers in oral health · 2025Article
- In vitro study of probiotic Lactobacillus helveticus: Antibacterial effects on Porphyromonas gingivalis.PloS one · 2025Article
- Metabolic reprogramming during Candida albicans planktonic-biofilm transition is modulated by the transcription factors Zcf15 and Zcf26.PLoS biology · 2024Article
- Contrasting genes conferring short- and long-term biofilm adaptation inMicrobial genomics · 2023Article
- What's in a name? Characteristics of clinical biofilms.FEMS microbiology reviews · 2023Article
- Establishment of Streptococcus suis Biofilm Infection ModelMicrobiology spectrum · 2023Article
- Mechanistic insights of magnolol antimicrobial activity againstFrontiers in cellular and infection microbiology · 2023Article
- Metabolomic and cultivation insights into the tolerance of the spacecraft-associatedFrontiers in microbiology · 2023Article
- Metabolic pathways that permitFrontiers in cellular and infection microbiology · 2023Article
- Natural phenolic compounds as biofilm inhibitors of multidrug-resistantFrontiers in microbiology · 2023Article
- Transcriptional Changes in Bifidobacterium bifidum Involved in Synergistic Multispecies Biofilms.Microbial ecology · 2022Article
- Analysis of the Metabolic Response of Planktonic Cells and Biofilms ofMicroorganisms · 2022Article
- Recent Strategies to Combat Biofilms Using Antimicrobial Agents and Therapeutic Approaches.Pathogens (Basel, Switzerland) · 2022Review
- "Omics" Technologies - What Have They Told Us About UropathogenicFrontiers in cellular and infection microbiology · 2022Review
- Cadaverine Is a Switch in the Lysine Degradation Pathway inFrontiers in cellular and infection microbiology · 2022Article
- Advances in experimental and computational methodologies for the study of microbial-surface interactions at different omics levels.Frontiers in microbiology · 2022Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biofilm formation plays a key role in many bacteria causing infections, which mostly accounts for high-frequency infectious recurrence and antibiotics resistance. In this study, we sought to compare modified metabolism of biofilm and planktonic populations with UTI89, a predominant agent of urinary tract infection, by combining mass spectrometry based untargeted and targeted metabolomics methods, as well as cytological visualization, which enable us to identify the driven metabolites and associated metabolic pathways underlying biofilm formation. Surprisingly, our finding revealed distinct differences in both phenotypic morphology and metabolism between two patterns. Furthermore, we identified and characterized 38 differential metabolites and associated three metabolic pathways involving glycerolipid metabolism, amino acid metabolism and carbohydrate metabolism that were altered mostly during biofilm formation. This discovery in metabolic phenotyping permitted biofilm formation shall provide us a novel insight into the dissociation of biofilm, which enable to develop novel biofilm based treatments against pathogen causing infections, with lower antibiotic resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.