Evidence map›Paper›PMID 31511544›Full record

ArticleScientific reports2019

Prion protein modulates endothelial to mesenchyme-like transition in trabecular meshwork cells: Implications for primary open angle glaucoma.

Ajay Ashok, Min H Kang, Aaron S Wise, P Pattabiraman, William M Johnson, Michael Lonigro, Ranjana Ravikumar, Douglas J Rhee, Neena Singh

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Beta-endoproteolysis of the cellular prion protein by dipeptidyl peptidase-4 and fibroblast activation protein.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Prions and prion diseases: Insights from the eye.Experimental eye research · 2020
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ajay AshokDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, 44106, USA.
Min H KangDepartment of Ophthalmology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, 44106, USA.
Aaron S WiseDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, 44106, USA.
P PattabiramanDepartment of Ophthalmology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, 44106, USA.
William M JohnsonDepartment of Ophthalmology, Duke University, Durham, NC, USA.
Michael LonigroDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, 44106, USA.
Ranjana RavikumarDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, 44106, USA.
Douglas J RheeDepartment of Ophthalmology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, 44106, USA.
Neena SinghDepartment of Pathology, School of Medicine, Case Western Reserve University, Cleveland, Ohio, 44106, USA. neena.singh@case.edu.
Case Western Reserve University · USDuke University · US

Funding

TISSUE CULTURE AND HYBRIDOMA MODULEP30EY011373 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Irina A Pikuleva · 1997 to 2026
$17.7M
The iron modulatory function of prion protein and prion disordersR01NS092145 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI SINGH, NEENA · 2015 to 2019
$2.4M
Local hepcidin in the anterior segment: Physiological and pathological implicationsR21EY032694 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI SINGH, NEENA · 2022 to 2023
$443k
NEI NIH HHS P30 EY011373NEI NIH HHS R21 EY032694NINDS NIH HHS R01 NS092145
6 · The paper itself

Abstract

Endothelial-to-mesenchyme-like transition (Endo-MT) of trabecular meshwork (TM) cells is known to be associated with primary open angle glaucoma (POAG). Here, we investigated whether the prion protein (PrP

Indexed as

AnimalsCattleEndothelial CellsGene Expression RegulationGene SilencingGlaucoma, Open-AngleHumansMesodermMicePrPC ProteinsTrabecular MeshworkPrPC Proteins

Identifiers

PMID31511544
PMCPMC6739364
OpenAlexW2972542992

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.