ArticleNature communications2019
Spontaneous whole-genome duplication restores fertility in interspecific hybrids.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Somatic genome-doubling is the most parsimonious route to allopolyploidy.The New phytologist · 2026Review
- Influence of Ploidy and Genetic Background on Stress Tolerance of Intraspecific Yeast Hybrids.Microbial biotechnology · 2026Article
- A Trojan horse inside the gates: Alien-native mating interactions in mixed populations of Solidago taxa.Plant biology (Stuttgart, Germany) · 2026Article
- Targeted genetic manipulation and yeast-like evolutionary genomics in the green alga Auxenochlorella.The Plant cell · 2025Article
- Whole-Genome Sequence of Potamopyrgus antipodarum-A Model System for the Maintenance of Sexual Reproduction-Reveals a Recent Whole-Genome Duplication.Genome biology and evolution · 2025Article
- Targeted genetic manipulation and yeast-like evolutionary genomics in the green algabioRxiv : the preprint server for biology · 2025Article
- Rapid formation of stable autotetraploid rice from genome-doubled F1 hybrids of japonica-indica subspecies.Nature plants · 2025Article
- The dynamics of loss of heterozygosity events in genomes.EMBO reports · 2025Review
- Bridging micro and macroevolution: insights from chromosomal dynamics in plants.Frontiers in plant science · 2025Review
- Hybrid adaptation is hampered by Haldane's sieve.Nature communications · 2024Article
- Article
- The Intransitive Logic of Directed Cycles and Flipons Enhances the Evolution of Molecular Computers by Augmenting the Kolmogorov Complexity of Genomes.International journal of molecular sciences · 2023Review
- Phylogenomic Analyses Reveal an Allopolyploid Origin of Core Didymocarpinae (Gesneriaceae) Followed by Rapid Radiation.Systematic biology · 2023Article
- Genome composition in Brassica interspecific hybrids affects chromosome inheritance and viability of progeny.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2023Article
- Loss of Heterozygosity and Its Importance in Evolution.Journal of molecular evolution · 2023Review
- Loss of Heterozygosity Spectrum Depends on Ploidy Level in Natural Yeast Populations.Molecular biology and evolution · 2022Article
- Evolution and molecular bases of reproductive isolation.Current opinion in genetics & development · 2022Review
- Genome doubling enabled the expansion of yeast vesicle traffic pathways.Scientific reports · 2022Article
- Heterogeneous Mutation Rates and Spectra in Yeast Hybrids.Genome biology and evolution · 2021Article
- Aborting meiosis allows recombination in sterile diploid yeast hybrids.Nature communications · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interspecies hybrids often show some advantages over parents but also frequently suffer from reduced fertility, which can sometimes be overcome through sexual reproduction that sorts out genetic incompatibilities. Sex is however inefficient due to the low viability or fertility of hybrid offspring and thus limits their evolutionary potential. Mitotic cell division could be an alternative to fertility recovery in species such as fungi that can also propagate asexually. Here, to test this, we evolve in parallel and under relaxed selection more than 600 diploid yeast inter-specific hybrids that span from 100,000 to 15 M years of divergence. We find that hybrids can recover fertility spontaneously and rapidly through whole-genome duplication. These events occur in both hybrids between young and well-established species. Our results show that the instability of ploidy in hybrid is an accessible path to spontaneous fertility recovery.
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