Evidence map›Paper›PMID 31511430›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Rehabilitative Training Interacts with Ischemia-Instigated Spine Dynamics to Promote a Lasting Population of New Synapses in Peri-Infarct Motor Cortex.

Taylor A Clark, Colin Sullender, Daron Jacob, Yi Zuo, Andrew K Dunn, Theresa A Jones

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Dietary Fenbendazole Treatment Does Not Impair Skilled Forelimb Motor Function in C57BL/6J Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025
    Article
  5. Neural repair mechanisms after ischemic stroke.Inflammation and regeneration · 2025
    Review
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  7. Detrimental influence of Arginase-1 in infiltrating macrophages on poststroke functional recovery and inflammatory milieu.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Taylor A ClarkInstitute for Neuroscience, clark.taylorann@utexas.edu.ORCID 0000-0002-4887-3850
Colin SullenderDepartment of Biomedical Engineering, University of Texas at Austin, Austin, Texas 78712.ORCID 0000-0003-4329-7708
Daron JacobSchool of Medicine, Texas Tech Health Sciences Center, Lubbock, Texas 79430, and.
Yi ZuoMolecular, Cell, and Developmental Biology, University of California at Santa Cruz, Santa Cruz, California 95064.ORCID 0000-0001-9020-0003
Andrew K DunnDepartment of Biomedical Engineering, University of Texas at Austin, Austin, Texas 78712.
Theresa A JonesInstitute for Neuroscience.ORCID 0000-0003-0906-6439
The University of Texas at Austin · USSociety for Neuroscience · USTexas Tech University Health Sciences Center · USUniversity of California, Santa Cruz · US

Funding

Neural Mechanisms of Compensating for Brain DamageR01NS056839 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI JONES, THERESA A · 2007 to 2016
$3.3M
Comprehensive Training Program in Imaging Science and InformaticsT32EB007507 · NIBIB · UNIVERSITY OF TEXAS AT AUSTIN · PI MARKEY, MIA K, RYLANDER, HENRY GRADY · 2009 to 2024
$2.7M
NEURAL MECHANISMS OF COMPENSATING FOR BRAIN DAMAGER37NS056839 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI JONES, THERESA A · 2018 to 2024
$2.6M
Neurovascular Mechanisms of Time-Dependencies in Stroke RehabilitationR01NS078791 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI DUNN, ANDREW K, JONES, THERESA A · 2012 to 2016
$1.7M
Sex-Dependent Aging Effects on Cortical Reorganization after StrokeR21NS101564 · NINDS · UNIVERSITY OF TEXAS AT AUSTIN · PI JONES, THERESA A · 2017 to 2018
$418k
NIBIB NIH HHS T32 EB007507NINDS NIH HHS R01 NS056839NINDS NIH HHS R01 NS078791NINDS NIH HHS R21 NS101564NINDS NIH HHS R37 NS056839
6 · The paper itself

Abstract

After subtotal infarcts of primary motor cortex (M1), motor rehabilitative training (RT) promotes improvements in paretic forelimb function that have been linked with its promotion of structural and functional reorganization of peri-infarct cortex, but how the reorganization unfolds is scantly understood. Cortical infarcts also instigate a prolonged period of dendritic spine turnover in peri-infarct cortex. Here we investigated the possibility that synaptic structural responses to RT in peri-infarct cortex reflect, in part, interactions with ischemia-instigated spine turnover. This was tested after artery-targeted photothrombotic M1 infarcts or Sham procedures in adult (4 months) C57BL/6 male and female GFP-M line (

Indexed as

Stroke RehabilitationAnimalsBrain IschemiaDendritic SpinesDisease Models, AnimalFemaleMaleMiceMotor CortexMotor SkillsNeuronal PlasticityRecovery of FunctionStrokeSynapsesdendritic spinesin vivo imagingischemiamouse modelsphotothrombosisrehabilitative training

Identifiers

PMID31511430
PMCPMC6807284
OpenAlexW2973089092

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.