ArticleJournal of lipid research2019
ApoF knockdown increases cholesteryl ester transfer to LDL and impairs cholesterol clearance in fat-fed hamsters.
Article in Journal of lipid research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
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- Lipid metabolism, microglia, and stroke.Neural regeneration research · 2026Article
- Human Plasma Proteomics Links Modifiable Lifestyle Exposome to Disease Risk.medRxiv : the preprint server for health sciences · 2025Article
- Mechanisms and consequences of myeloid adhesome dysfunction in atherogenesis.Cardiovascular research · 2025Article
- Multi-omics analysis reveals novel causal pathways in psoriasis pathogenesis.Journal of translational medicine · 2025Article
- Hic-5 antisense oligonucleotide inhibits advanced hepatic fibrosis and steatosisJHEP reports : innovation in hepatology · 2024Article
- Plasma proteins and inflammatory dermatoses: proteome-wide Mendelian randomization and colocalization analyses.Archives of dermatological research · 2024Article
- A pan-cancer analysis of the oncogenic and immunological roles of apolipoprotein F (APOF) in human cancer.European journal of medical research · 2023Article
- The Roles of Fatty Acids and Apolipoproteins in the Kidneys.Metabolites · 2022Review
- Apolipoprotein F concentration, activity, and the properties of LDL controlling ApoF activation in hyperlipidemic plasma.Journal of lipid research · 2022Article
- Article
- Identification of key genes affecting porcine fat deposition based on co-expression network analysis of weighted genes.Journal of animal science and biotechnology · 2021Article
- Beyond Lipoprotein(a) plasma measurements: Lipoprotein(a) and inflammation.Pharmacological research · 2021Review
- β-catenin-promoted cholesterol metabolism protects against cellular senescence in naked mole-rat cells.Communications biology · 2021Article
- Combined Transcriptomic and Lipidomic Analysis Reveals Dysregulated Genes Expression and Lipid Metabolism Profiles in the Early Stage of Fatty Liver Disease in Rats.Frontiers in nutrition · 2021Article
- Apolipoprotein F: a natural inhibitor of cholesteryl ester transfer protein and a key regulator of lipoprotein metabolism.Current opinion in lipidology · 2020Review
- The lipid transfer properties of CETP define the concentration and composition of plasma lipoproteins.Journal of lipid research · 2020Article
- Article
- Identification of a hormone response element that mediates suppression of APOF by LXR and PPARα agonists.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cholesteryl ester transfer protein (CETP) regulates intravascular lipoprotein metabolism. In vitro studies indicate that ApoF alters CETP function by inhibiting its activity with LDL. To explore in vivo the complexities driving ApoF's effects on CETP, we developed a siRNA-based hamster model of ApoF knockdown. In both male and female hamsters on chow- or fat-fed diets, we measured lipoprotein levels and composition, determined CETP-mediated transfer of cholesteryl esters (CEs) between lipoproteins, and quantified reverse cholesterol transport (RCT). We found that apoF knockdown in chow-fed hamsters had no effect on lipoprotein levels or composition, but these ApoF-deficient lipoproteins supported 50-100% higher LDL CETP activity in vitro. ApoF knockdown in fat-fed male hamsters created a phenotype in which endogenous CETP-mediated CE transfer from HDL to LDL increased up to 2-fold, LDL cholesterol increased 40%, HDL declined 25%, LDL and HDL lipid compositions were altered, and hepatic
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.