Evidence map›Paper›PMID 31511393›Full record

ArticleJournal of virology2019

Influenza Viruses in Mice: Deep Sequencing Analysis of Serial Passage and Effects of Sialic Acid Structural Variation.

Brian R Wasik, Ian E H Voorhees, Karen N Barnard, Brynn K Alford-Lawrence, Wendy S Weichert, Grace Hood, Aitor Nogales, Luis Martínez-Sobrido, Edward C Holmes, Colin R Parrish

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Brian R WasikBaker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.ORCID 0000-0001-5442-3883
Ian E H VoorheesBaker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.ORCID 0000-0003-3189-1101
Karen N BarnardBaker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.ORCID 0000-0001-6283-4543
Brynn K Alford-LawrenceBaker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Wendy S WeichertBaker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Grace HoodBaker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA.
Aitor NogalesDepartment of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA.ORCID 0000-0002-2424-7900
Luis Martínez-SobridoDepartment of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA.ORCID 0000-0001-7084-0804
Edward C HolmesMarie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.ORCID 0000-0001-9596-3552
Colin R ParrishBaker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York, USA crp3@cornell.edu.ORCID 0000-0002-1836-6655
Cornell University · USUniversity of Rochester Medical Center · USThe University of Queensland · AUThe University of Sydney · AU

Funding

The Evolutionary and Biological Bases of Host Switching in VirusesR01GM080533 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI PARRISH, COLIN R. · 2007 to 2019
$4.1M
NIAID NIH HHS HHSN272201400008CNIGMS NIH HHS R01 GM080533
6 · The paper itself

Abstract

Influenza A viruses have regularly jumped to new host species to cause epidemics or pandemics, an evolutionary process that involves variation in the viral traits necessary to overcome host barriers and facilitate transmission. Mice are not a natural host for influenza virus but are frequently used as models in studies of pathogenesis, often after multiple passages to achieve higher viral titers that result in clinical disease such as weight loss or death. Here, we examine the processes of influenza A virus infection and evolution in mice by comparing single nucleotide variations of a human H1N1 pandemic virus, a seasonal H3N2 virus, and an H3N2 canine influenza virus during experimental passage. We also compared replication and sequence variation in wild-type mice expressing

Indexed as

AnimalsBiological EvolutionDisease Models, AnimalDogsHigh-Throughput Nucleotide SequencingHost SpecificityHumansInfluenza A virusInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeInfluenza, HumanLungMadin Darby Canine Kidney CellsMiceMice, Inbred C57BLMice, KnockoutCMPacetylneuraminate monooxygenaseMixed Function OxygenasesN-Acetylneuraminic Acidanimal modelsevolutionhost rangeinfluenzasialic acid

Identifiers

PMID31511393
PMCPMC6854484
OpenAlexW2972957767

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.