Evidence map›Paper›PMID 31511367›Full record

ArticlemSphere2019

Serological Array-in-Well Multiplex Assay Reveals a High Rate of Respiratory Virus Infections and Reinfections in Young Children.

Anna Kazakova, Laura Kakkola, Henna Päkkilä, Tamara Teros-Jaakkola, Tero Soukka, Ville Peltola, Matti Waris, Ilkka Julkunen

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Anna KazakovaInstitute of Biomedicine, University of Turku, Turku, Finland.
Laura KakkolaInstitute of Biomedicine, University of Turku, Turku, Finland.
Henna PäkkiläDepartment of Biotechnology, University of Turku, Turku, Finland.
Tamara Teros-JaakkolaDepartment of Pediatrics and Adolescent Medicine, Turku University Hospital, University of Turku, Turku, Finland.
Tero SoukkaDepartment of Biotechnology, University of Turku, Turku, Finland.
Ville PeltolaDepartment of Pediatrics and Adolescent Medicine, Turku University Hospital, University of Turku, Turku, Finland.
Matti WarisInstitute of Biomedicine, University of Turku, Turku, Finland matti.waris@utu.fi.ORCID 0000-0002-6747-0889
Ilkka JulkunenInstitute of Biomedicine, University of Turku, Turku, Finland.
University of Turku · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serological assays are used to diagnose and characterize host immune responses against microbial pathogens. Microarray technologies facilitate high-throughput immunoassays of antibody detection against multiple pathogens simultaneously. To improve survey of influenza A virus (IAV), influenza B virus (IBV), respiratory syncytial virus (RSV), and adenovirus (AdV) antibody levels, we developed a microarray consisting of IAV H1N1, IAV H1N1pdm09 (vaccine), IAV H3N2, IBV Victoria, IBV Yamagata, RSV, AdV type 5 hexon protein, and control antigens printed on the bottom of a microtiter plate well. Bound IgG antibodies were detected with anti-human IgG-coated photon-upconverting nanoparticles and measured with a photoluminescence imager. The performance of the microarray immunoassay (MAIA) was evaluated with serum samples (

Indexed as

AdenoviridaeAntibodies, ViralChild, PreschoolCohort StudiesHigh-Throughput Screening AssaysHumansImmunoassayInfantInfluenza A virusInfluenza B virusMicroarray AnalysisObservational Studies as TopicRespiratory Syncytial VirusesRespiratory Tract InfectionsSerologic TestsVirusesAntibodies, Viraladenovirusesimmunoassaysinfluenzainfluenza vaccinesmicroarraymultiplexrespiratory syncytial virusupconversion luminescence

Identifiers

PMID31511367
PMCPMC6739493
OpenAlexW2973117197

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.