ReviewJournal of the American Society of Nephrology : JASN2019
Intradialytic Cerebral Hypoperfusion as Mechanism for Cognitive Impairment in Patients on Hemodialysis.
Review in Journal of the American Society of Nephrology : JASN, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Kidney function and cognitive impairment: a systematic review and meta-analysis.Renal failure · 2025Pooled it
- Benefits of resistant starch type 2 for patients with end-stage renal disease under maintenance hemodialysis: a systematic review and meta-analysis.International journal of medical sciences · 2021Pooled it
- The impact of intradialytic elastic band exercise on physical and cognitive abilities in patients on maintenance hemodialysis: a randomized controlled trial.Renal failure · 2025Trial
- Quantitative Electroencephalography in Hemodialysis: Scoping Review and Translational Framework.JMIR biomedical engineering · 2026Review
- Neuro-Renal Crosstalk Across the Chronic Kidney Disease Spectrum: Stage-Dependent Molecular Mechanisms of Cognitive Impairment-An Integrative Review.International journal of molecular sciences · 2026Review
- Fatigue and Cognitive Impairment in Patients with Kidney Failure Not Requiring Kidney Replacement Therapy and Patients Receiving Hemodialysis: A Cross-Sectional Study.Brain sciences · 2026Article
- Frailty and incident cognitive impairment in patients with CKD: sex-frailty paradox in the Chronic Renal Insufficiency Cohort (CRIC).GeroScience · 2026Article
- Sex Differences in Dementia and Mild Cognitive Impairment in Nondialysis CKD.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Intradialytic cerebral blood flow reduction occurs irrespective of vascular access type: a comparative study.BMC nephrology · 2026Article
- Effect of haemodialysis on the brain and heart assessed using multiparametric MRI.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Article
- Article
- Dialysis and cognitive impairment.Nature reviews. Nephrology · 2025Review
- The impaired white-matter structural network mediates the relationship between the glymphatic system and emotional abnormalities in patients with chronic kidney disease.Quantitative imaging in medicine and surgery · 2025Article
- Diagnosis and Management of Dementia for the Nephrology Clinician: A Review.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2025Review
- Cerebrovascular Reactivity and Cerebral Ischemia During Chronic Hemodialysis.Hemodialysis international. International Symposium on Home Hemodialysis · 2025Article
- Prevalence and Pattern of Cognitive Impairment in Patients on Maintenance Hemodialysis.Cureus · 2025Article
- Cognitive impairment in chronic kidney disease: role of brain imaging, functional imaging, electroencephalography, cerebrospinal fluid biomarkers and sensors.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Review
- Acute Effect of Moderate-Intensity Interval Intradialytic Exercise on Cerebral Oxygenation in Hemodialysis Patients: A Randomized Crossover Trial.Journal of the American Society of Nephrology : JASN · 2025Article
- Fatigue in Hemodialysis Patients: A Comparative Analysis with Healthy Controls.European journal of investigation in health, psychology and education · 2025Article
- Brain surface area and function alterations are correlated with cognition in patients with end-stage renal disease.Quantitative imaging in medicine and surgery · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
The high frequency of cognitive impairment in individuals on hemodialysis is well characterized. In-center hemodialysis patients are disproportionately affected by cognitive impairment compared with other dialysis populations, identifying hemodialysis itself as a possible factor. The pathophysiology of cognitive impairment has multiple components, but vascular-mediated cerebral injury appears to contribute based on studies demonstrating increased cerebral ischemic lesions and atrophy in brain imaging of patients on hemodialysis. Patients on hemodialysis may be at increased risk for cerebral ischemic injury disease due to vasculopathy associated with ESKD and from their comorbid diseases, such as hypertension and diabetes. This review focuses on the intradialytic cerebral hypoperfusion that can occur during routine hemodialysis due to the circulatory stress of hemodialysis. This includes a review of current methods used to monitor intradialytic cerebral perfusion and the structural and functional cognitive outcomes that have been associated with changes in intradialytic cerebral perfusion. Monitoring of intradialytic cerebral perfusion may become clinically relevant as nephrologists try to avoid the cognitive complications seen with hemodialysis. Identifying the appropriate methods to assess risk for cerebral ischemic injury and the relationship of intradialytic cerebral hypoperfusion to cognitive outcomes will help inform the decision to use intradialytic cerebral perfusion monitoring in the clinical setting as part of a strategy to prevent cognitive decline.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.