Evidence map›Paper›PMID 31511352›Full record

ArticleMolecular cancer therapeutics2019

Suppression of Nuclear Factor-κB by Glucocorticoid Receptor Blocks Estrogen-Induced Apoptosis in Estrogen-Deprived Breast Cancer Cells.

Ping Fan, Doris R Siwak, Balkees Abderrahman, Fadeke A Agboke, Smitha Yerrum, V Craig Jordan

Abstract read
In one paragraph

Article in Molecular cancer therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 24 citations in OpenAlex.

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  17. New insights into acquired endocrine resistance of breast cancer.Cancer drug resistance (Alhambra, Calif.) · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ping FanDepartment of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Doris R SiwakDepartment of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Balkees AbderrahmanDepartment of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Fadeke A AgbokeDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, D.C.
Smitha YerrumDepartment of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
V Craig JordanDepartment of Breast Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. VCJordan@mdanderson.org.
The University of Texas MD Anderson Cancer Center · USGeorgetown University · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

Our clinically relevant finding is that glucocorticoids block estrogen (E

Indexed as

ApoptosisBreast NeoplasmsDelta-5 Fatty Acid DesaturaseDexamethasoneDNA, NeoplasmeIF-2 KinaseEndoplasmic Reticulum StressEndoribonucleasesEstrogensFemaleGene Expression Regulation, NeoplasticHumansInflammationMCF-7 CellsNF-kappa BPhosphatidylinositol 3-KinasesDelta-5 Fatty Acid DesaturaseDexamethasoneDNA, NeoplasmEIF2AK3 protein, humaneIF-2 KinaseEndoribonucleasesERN1 protein, humanEstrogensFADS1 protein, humanNF-kappa BPhosphatidylinositol 3-KinasesProtein Serine-Threonine KinasesReceptors, GlucocorticoidTumor Necrosis Factor-alpha

Identifiers

PMID31511352
PMCPMC6774891
OpenAlexW2972822013

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.