Evidence map›Paper›PMID 31511338›Full record

ArticleJournal of clinical microbiology2019

Rapid Tuberculosis Diagnosis Using Reporter Enzyme Fluorescence.

Preeti Sule, Ronak Tilvawala, Toriq Mustapha, Hany Hassounah, Aneesa Noormohamed, Suprateek Kundu, Edward A Graviss, Grant K Walkup, Ying Kong, Jeffrey D Cirillo

Abstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Expert review of respiratory medicine · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Revisiting the methods for detectingAccess microbiology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Preeti SuleDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, Texas, USA.
Ronak TilvawalaDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, Texas, USA.
Toriq MustaphaDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, Texas, USA.
Hany HassounahDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, Texas, USA.
Aneesa NoormohamedDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, Texas, USA.
Suprateek KunduDepartment of Biostatistics & Bioinformatics, Emory University, Atlanta, Georgia, USA.
Edward A GravissDepartment of Pathology and Genomic Medicine, Houston Methodist Research Institute, Houston, Texas, USA.
Grant K WalkupAgios Pharmaceuticals, Cambridge, Massachusetts, USA.
Ying KongDepartment of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Jeffrey D CirilloDepartment of Microbial Pathogenesis and Immunology, Texas A&M Health Science Center, Bryan, Texas, USA jdcirillo@tamu.edu.ORCID 0000-0003-3058-2702

Funding

Application of Imaging to Development of Tuberculosis InterventionsR01AI104960 · NIAID · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI CIRILLO, JEFFREY D. · 2014 to 2018
$1.9M
Non-invasive Fluorescent Imaging Mycobacterium tuberculosis Extrapulmonary InfectR21HL115463 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI KONG, YING · 2012 to 2013
$391k
NHLBI NIH HHS R21 HL115463NIAID NIH HHS R01 AI104960Wellcome Trust 100598
6 · The paper itself

Abstract

Tuberculosis is the most frequent cause of death in humans from a single infectious agent. Due to low numbers of bacteria present in sputum during early infection, diagnosis does not usually occur until >3 to 4 months after symptoms develop. We created a new more sensitive diagnostic that can be carried out in 10 min with no processing or technical expertise. This assay utilizes the

Indexed as

AdolescentAdultAgedAged, 80 and overbeta-LactamasesDiagnostic Tests, RoutineFemaleFluorescent DyesFluorometryHumansMaleMiddle AgedMycobacterium tuberculosisPredictive Value of TestsSensitivity and SpecificityTime Factorsbeta-LactamasesFluorescent DyesbiomarkerBlaClactamaseMycobacterium tuberculosispoint of care

Identifiers

PMID31511338
PMCPMC6879286

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.