Evidence map›Paper›PMID 31511320›Full record

ArticleRNA (New York, N.Y.)2019

HNRNPH1-dependent splicing of a fusion oncogene reveals a targetable RNA G-quadruplex interaction.

Carla Neckles, Robert E Boer, Nicholas Aboreden, Allison M Cross, Robert L Walker, Bong-Hyun Kim, Suntae Kim, John S Schneekloth, Natasha J Caplen

Open access · bronzeAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 47 citations in OpenAlex.

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  5. HNRNPH1-mediated splicing events regulatebioRxiv : the preprint server for biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Carla NecklesFunctional Genetics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.
Robert E BoerChemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA.
Nicholas AboredenFunctional Genetics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.
Allison M CrossFunctional Genetics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.
Robert L WalkerMolecular Genetics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.
Bong-Hyun KimCCR Collaborative Bioinformatics Resource, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, Maryland 21702, USA.
Suntae KimFunctional Genetics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.
John S SchneeklothChemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA.
Natasha J CaplenFunctional Genetics Section, Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA.ORCID 0000-0002-0001-9460
National Cancer Institute · USFrederick National Laboratory for Cancer Research · USLeidos (United States) · US

Funding

CCR Office of Training and EducationZIJBC011133 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CLARK, SHAUNA · 2009 to 2025
$36.8M
Identification of Nucleic Acid Binding Small MoleculesZIABC011585 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SCHNEEKLOTH, JOHN · 2014 to 2025
$18.6M
Discovery of genes required for expression or activity of fusion oncogenesZIABC011704 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CAPLEN, NATASHA · 2016 to 2025
$15.8M
CCR NIH HHS HHSN261200800001CIntramural NIH HHS ZIA BC011585Intramural NIH HHS ZIA BC011704Intramural NIH HHS ZIJ BC011133NCI NIH HHS HHSN261200800001E
6 · The paper itself

Abstract

The primary oncogenic event in ∼85% of Ewing sarcomas is a chromosomal translocation that generates a fusion oncogene encoding an aberrant transcription factor. The exact genomic breakpoints within the translocated genes,

Indexed as

G-QuadruplexesRNA SplicingHeterogeneous-Nuclear RibonucleoproteinsOncogene Proteins, FusionProtein BindingRNA-Binding ProteinsRNA, MessengerHeterogeneous-Nuclear RibonucleoproteinsOncogene Proteins, FusionRNA-Binding ProteinsRNA, MessengerEwing sarcomaEWS–FLI1EWSR1G-quadruplexHNRNPH1splicing

Identifiers

PMID31511320
PMCPMC6859848
OpenAlexW2972510413

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.