Evidence map›Paper›PMID 31511252›Full record

ArticleDevelopment (Cambridge, England)2019

Developmentally regulated

Iain Williamson, Lauren Kane, Paul S Devenney, Ilya M Flyamer, Eve Anderson, Fiona Kilanowski, Robert E Hill, Wendy A Bickmore, Laura A Lettice

Open access · greenAbstract read
In one paragraph

Article in Development (Cambridge, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed
8.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 149 citations in OpenAlex.

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  14. Divergent 3D genome organization in livers of cave and surface morphs ofbioRxiv : the preprint server for biology · 2025
    Article
  15. A 3D Genome Atlas of Genetic Variants and Their Pathological Effects in Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Iain WilliamsonMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK.
Lauren KaneMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK.ORCID 0000-0002-7210-7160
Paul S DevenneyMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK.
Ilya M FlyamerMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK.
Eve AndersonMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK.
Fiona KilanowskiMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK.
Robert E HillMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK.
Wendy A BickmoreMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK Wendy.Bickmore@igmm.ed.ac.uk Laura.Lettice@igmm.ed.ac.uk.ORCID 0000-0001-6660-7735
Laura A LetticeMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK Wendy.Bickmore@igmm.ed.ac.uk Laura.Lettice@igmm.ed.ac.uk.ORCID 0000-0002-4294-8970
Institute of Genetics and Cancer · GB

Funding

Medical Research Council MC_UU_00007/2Medical Research Council MC_UU_00007/8
6 · The paper itself

Abstract

Topologically associating domains (TADs) have been proposed to both guide and constrain enhancer activity.

Indexed as

Gene Expression Regulation, DevelopmentalAnimalsBase PairingCCCTC-Binding FactorChromatinEmbryo, MammalianEnhancer Elements, GeneticExtremitiesGenomeHedgehog ProteinsMiceOrgan SpecificityPhenotypeSequence DeletionCCCTC-Binding FactorChromatinHedgehog ProteinsShh protein, mouseChromosome conformation captureDevelopmentEnhancersFluorescence in situ hybridisationGenome organisationShhTopologically associated domains

Identifiers

PMID31511252
PMCPMC7212092
OpenAlexW2973219761

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.