Evidence map›Paper›PMID 31511216›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2019

[Effect of propofol on myelin basic protein expression and myelination of oligodendrocytes in neonatal SD rats].

Xin Zhang, Chunshui Lin, Peipei Guo, Jun Qin, Xiuxiu Qin, Weidong Liang

Abstract read
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. [Mechanism of propofol-induced apoptosis in neonatal rat oligodendrocytes].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Xin ZhangDepartment of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Chunshui LinDepartment of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Peipei GuoDepartment of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Jun QinDepartment of Anesthesiology, Longgang Orthopedics Hospital, Shenzhen 518116, China.
Xiuxiu QinDepartment of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Weidong LiangDepartment of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Nanfang Hospital · CNSouthern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the effects of different doses of propofol on myelin basic protein (MBP) synthesis and myelination of oligodendrocytes in neonatal SD rats.

methodsA total of 57 neonatal SD rats (7 days old) were randomly divided into control group (

resultsCompared with the control group, the neonatal rats with propofol injections showed significantly down-regulated expressions of

conclusionsIn neonatal SD rats, propofol can dose-dependently promote oligodendrocyte apoptosis, decrease MBP expressions in the brain, and suppress myelin formation in the corpus callosum and the internal capsule.

Indexed as

OligodendrogliaAnimalsMyelin Basic ProteinPropofolRatsRats, Sprague-DawleyRNA, MessengerMyelin Basic ProteinPropofolRNA, Messengermyelin basic proteinmyelin sheathneonatesoligodendrocytespropofol

Identifiers

PMID31511216
PMCPMC6765605
OpenAlexW2976849399

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.