ArticleCritical care (London, England)2019
Transfusion practice in the non-bleeding critically ill: an international online survey-the TRACE survey.
Article in Critical care (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06560164 (Restrictive Versus Liberal Thresholds for Red Blood Cell Transfusion in ExtraCorporeal Membrane Oxygenation - the TREC Study), which is not on this map. Cited by 32 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Restrictive Versus Liberal Thresholds for Red Blood Cell Transfusion in ExtraCorporeal Membrane Oxygenation - the TREC Study
Who cites it
32 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Prophylactic platelet transfusions versus no prophylaxis in hospitalized patients with thrombocytopenia: A systematic review with meta-analysis.Transfusion · 2022Pooled it
- Transfusion thresholds for guiding red blood cell transfusion.The Cochrane database of systematic reviews · 2021Pooled it
- Transfusion strategies in bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine.Intensive care medicine · 2021Guideline
- Transfusion strategies in non-bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine.Intensive care medicine · 2020Guideline
- Transfusion intensity in the ICU: Reasons and triggers.Transfusion · 2026Article
- Physiological determinants and the red blood cells transfusion decision-making process in non-bleeding critically ill patients: a comprehensive narrative review.Intensive care medicine · 2026Review
- Global transfusion practices in septic patients in the intensive care unit: insights from the InPUT-study sub-analysis.Transfusion · 2025Observational
- Postresuscitation platelet transfusion in major trauma patients.Transfusion · 2025Article
- Platelet transfusion practice in the intensive care unit: the Nine-I international platelet transfusion survey.Annals of intensive care · 2025Article
- How experienced ICU specialists make decisions on prophylactic platelet transfusions-A qualitative study.Transfusion · 2025Article
- Association between fibrinogen levels and prognosis in critically bleeding patients: exploration of the optimal therapeutic threshold.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
- Plasma transfusion in the intensive care unit.Transfusion · 2025Observational
- Vitamin K: a potential missing link in critical illness-a scoping review.Critical care (London, England) · 2024Article
- Prophylactic platelet transfusions in critical care: How low can you go?Journal of the Intensive Care Society · 2024Article
- Clinical Use of Canine Thawed Refrigerated Plasma: A Historical Case Series.Animals : an open access journal from MDPI · 2023Article
- Patient Blood Management, Anemia, and Transfusion Optimization Across Surgical Specialties.Anesthesiology clinics · 2023Review
- A Retrospective Cohort Study of Red Cell Alloimmunisation in Rural, Remote, and Aboriginal and Torres Strait Islander Peoples Admitted to Intensive Care in the Northern Territory, Australia.Journal of clinical medicine · 2023Article
- Major haemorrhage: past, present and future.Anaesthesia · 2023Review
- Knowledge gaps and research priorities in adult veno-arterial extracorporeal membrane oxygenation: a scoping review.Intensive care medicine experimental · 2022Article
- Appropriateness of red cell transfusion practices in an intensive care unit: A prospective observational study.Indian journal of anaesthesia · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundOver the last decade, multiple large randomized controlled trials have studied alternative transfusion strategies in critically ill patients, demonstrating the safety of restrictive transfusion strategies. Due to the lack of international guidelines specific for the intensive care unit (ICU), we hypothesized that a large heterogeneity in transfusion practice in this patient population exists. The aims of this study were to describe the current transfusion practices and identify the knowledge gaps.
methodsAn online, anonymous, worldwide survey among ICU physicians was performed evaluating red blood cell, platelet and plasma transfusion practices. Furthermore, the presence of a hospital- or ICU-specific transfusion guideline was asked. Only completed surveys were analysed.
resultsNine hundred forty-seven respondents filled in the survey of which 725 could be analysed. Hospital transfusion protocol available in their ICU was reported by 53% of the respondents. Only 29% of respondents used an ICU-specific transfusion guideline. The reported haemoglobin (Hb) threshold for the general ICU population was 7 g/dL (7-7). The highest reported variation in transfusion threshold was in patients on extracorporeal membrane oxygenation or with brain injury (8 g/dL (7.0-9.0)). Platelets were transfused at a median count of 20 × 10
conclusionRed blood cell transfusion practice for the general ICU population is restrictive, while for different subpopulations, higher Hb thresholds are applied. Furthermore, practice in plasma and platelet transfusion is heterogeneous, and local transfusion guidelines are lacking in the majority of the ICUs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.