ArticleParasites & vectors2019
Prevalence of the emerging novel Alongshan virus infection in sheep and cattle in Inner Mongolia, northeastern China.
Article in Parasites & vectors, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 71 citations in OpenAlex.
- Human 3D liver spheroids support productive infection of a novel tick-borne phenuivirus.One health (Amsterdam, Netherlands) · 2026Article
- The risk of pathogenic tick-borne viruses in Northeast Asia: a genomic and ecological modelling study.Science China. Life sciences · 2026Article
- Alongshan virus in the virome of Ixodes hexagonus ticks in the United Kingdom.Ticks and tick-borne diseases · 2026Article
- The segmented flavivirus ALSV-encoded nucleoprotein VP2 inhibits type I interferon production by targeting RIG-I.Microbiology spectrum · 2026Article
- Evaluation of the vector competence ofFrontiers in cellular and infection microbiology · 2026Article
- Two TaqMan real-time quantitative PCR assays for the detection of Alongshan virus, a new member of the tick-borne Flaviviridae family.Access microbiology · 2026Article
- Molecular detection of human-derived Jingmenvirus in multiple mosquito species from Yaoundé, Cameroon.Parasites & vectors · 2025Article
- Review
- Diversity of the Alongshan Virus inMicroorganisms · 2025Article
- A new potential mosquito-borne virus: detection of Human-derived Jingmenvirus in several-species of mosquitoes from Yaoundé, Cameroon.Research square · 2025Article
- Development of a loop-mediated isothermal amplification assay for the rapid detection of Alongshan virus.The Journal of general virology · 2025Article
- Review
- Exploring the potential of tick transcriptomes for virus screening: A data reuse approach for tick-borne virus surveillance.PLoS neglected tropical diseases · 2025Article
- The segmented flavivirus Alongshan virus reduces mitochondrial mass by degrading STAT2 to suppress the innate immune response.Journal of virology · 2025Article
- Identification of a putative new virus from theVirus evolution · 2025Article
- Virome analysis and detection of ticks and tick-borne viruses in Shanghai, China.Frontiers in microbiology · 2025Article
- Article
- Epidemiology and global spread of emerging tick-borne Alongshan virus.Emerging microbes & infections · 2024Review
- Metatranscriptomic analysis reveals the diversity of RNA viruses in ticks in Inner Mongolia, China.PLoS neglected tropical diseases · 2024Article
- Vectorial dynamics underpinning current and future tick-borne virus emergence in Europe.The Journal of general virology · 2024Review
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundAlongshan virus (ALSV) is a novel discovered segmented flavivirus associated with human febrile illness in northeastern China. Ixodes persulcatus is considered as a candidate vector of ALSV in the endemic regions. However, the role of domesticated animals in the circulation and transmission of ALSV have not been investigated. To evaluate the prevalence of ALSV infections in domesticated animals, viral RNA and viral specific antibodies were detected in sheep and cattle in Hulunbuir of northeastern Inner Mongolia. The findings contribute to the understanding of the ecology and transmission of ALSV among different natural hosts.
methodsA total of 480 animal serum samples were collected in Hulunbuir of northeastern China in May, 2017. Viral specific antibodies were tested by indirect enzyme-linked immunosorbent assay (ELISA) with a purified E. coli recombinant capsid protein (VP2) of ALSV (strain H3) and further detected by viral neutralization test (VNT). RNA in serum samples were extracted and detected for ALSV sequence by quantitative real-time RT-PCR. ALSV RNA positive samples were used for virus isolation.
resultsALSV-specific antibodies were detected in 9.2% (22/240) of examined sheep and 4.6% (11/240) of examined cattle by ELISA, while lower serological positivity with 4.2% (10/240) for sheep and 1.7% (4/240) for cattle was confirmed by VNT. In contrast, the prevalence of ALSV RNA was much higher, ranging from 26.3% (63/240) in sheep to 27.5% (66/240) in cattle. The partial S1 (NS5-like) and S3 (NS3-like) segments of ALSVs in sheep and cattle shared high identities of more than 98% to the human and tick isolates in the studied regions.
conclusionsThese results suggest that the natural infection of ALSV can be found in sheep and cattle in the endemic regions.
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