Evidence map›Paper›PMID 31510873›Full record

ArticleJournal of the American Heart Association2019

POT1 and Damage Response Malfunction Trigger Acquisition of Somatic Activating Mutations in the VEGF Pathway in Cardiac Angiosarcomas.

Oriol Calvete, Pablo Garcia-Pavia, Fernando Domínguez, Lluc Mosteiro, Lucía Pérez-Cabornero, Diego Cantalapiedra, Esther Zorio, Teresa Ramón Y Cajal, Maria G Crespo-Leiro, Álex Teulé and 4 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Primary cardiac angiosarcoma: From pathogenesis to therapeutic strategies.Medical oncology (Northwood, London, England) · 2026
    Review
  2. Review
  3. GermlineGenes · 2024
    Review
  4. Telomeres and telomerase in Sarcoma disease and therapy.International journal of medical sciences · 2024
    Review
  5. Case report: GermlineFrontiers in oncology · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 1 country.

Oriol CalveteHuman Genetics Group Spanish National Cancer Research Center (CNIO) Madrid Spain.
Pablo Garcia-PaviaDepartment of Cardiology Hospital Universitario Puerta de Hierro Madrid Spain.
Fernando DomínguezDepartment of Cardiology Hospital Universitario Puerta de Hierro Madrid Spain.
Lluc MosteiroTumour Suppression Group Spanish National Cancer Research Center (CNIO) Madrid Spain.
Lucía Pérez-CaborneroMedical Genetics Unit Sistemas Genómicos Parque Tecnológico de Valencia Paterna Spain.
Diego CantalapiedraMedical Genetics Unit Sistemas Genómicos Parque Tecnológico de Valencia Paterna Spain.
Esther ZorioDepartment of Cardiology Hospital Universitario y Politécnico La Fe Valencia Spain.
Teresa Ramón Y CajalMedical Oncology Service Hospital Sant Pau Barcelona Spain.
Maria G Crespo-LeiroDepartment of Cardiology Hospital Universitario Puerta de Hierro Madrid Spain.
Álex TeuléHereditary Cancer Program-Medical Oncology Service Catalan Institute of Oncology ICO-IDIBELL and CIBERONC Barcelona Spain.
Conxi LázaroMedical Oncology Service Catalan Institute of Oncology ICO-IDIBELL and CIBERONC Barcelona Spain.
Manuel M MorenteBiobank Unit Spanish National Cancer Research Center (CNIO) Madrid Spain.
Miguel UriosteCenter for Biomedical Network Research on Rare Diseases (CIBERER) Madrid Spain.
Javier BenitezHuman Genetics Group Spanish National Cancer Research Center (CNIO) Madrid Spain.
Centro de Investigación del Cáncer · ESCentre for Biomedical Network Research on Rare Diseases · ESSistemas Genómicos · ESComplexo Hospitalario Universitario A Coruña · ESHospital de Sant Pau · ESHospital Universitari i Politècnic La Fe · ESInstitut Català d'Oncologia · ESInstitut d'Investigació Biomédica de Bellvitge · ESSpanish National Centre for Cardiovascular Research · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background Mutations in the

Indexed as

ApoptosisAtaxia Telangiectasia Mutated ProteinsCarcinogenesisCase-Control StudiesCell Cycle CheckpointsDNA-Binding ProteinsDNA DamageExome SequencingHeart NeoplasmsHemangiosarcomaHumansImmunohistochemistryMutationNeovascularization, PathologicShelterin ComplexSignal TransductionARID1A protein, humanAtaxia Telangiectasia Mutated ProteinsATM protein, humanATR protein, humanDNA-Binding ProteinsG-T mismatch-binding proteinKDR protein, humanPOT1 protein, humanShelterin ComplexTelomere-Binding ProteinsTP53 protein, humanTranscription FactorsTumor Suppressor Protein p53Vascular Endothelial Growth Factor Receptor-2cardiac angiosarcomacell cycle arrestdamage responsePOT1VEGF/angiogenesis pathway

Identifiers

PMID31510873
PMCPMC6818007
OpenAlexW2972913514

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.