Evidence map›Paper›PMID 31510847›Full record

ArticleEpigenetics2020

Placental NEGR1 DNA methylation is associated with BMI and neurodevelopment in preschool-age children.

E Breton, V Gagné-Ouellet, K Thibeault, R Guérin, Rj Van Lieshout, P Perron, Mf Hivert, L Bouchard

Open access · bronzeAbstract read
In one paragraph

Article in Epigenetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Placental biomarkers for the prediction of neurodevelopmental disorders.Frontiers in cell and developmental biology · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Recent progress in epigenetics of obesity.Diabetology & metabolic syndrome · 2022
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

E BretonDepartment of Biochemistry, Université de Sherbrooke, Sherbrooke, QC, Canada.ORCID 0000-0002-8498-3133
V Gagné-OuelletDepartment of Biochemistry, Université de Sherbrooke, Sherbrooke, QC, Canada.
K ThibeaultDepartment of Biochemistry, Université de Sherbrooke, Sherbrooke, QC, Canada.
R GuérinDepartment of Biochemistry, Université de Sherbrooke, Sherbrooke, QC, Canada.
Rj Van LieshoutDepartment of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada.
P PerronDepartment of Medicine, Université de Sherbrooke, Sherbrooke, QC, Canada.
Mf HivertDepartment of Medicine, Université de Sherbrooke, Sherbrooke, QC, Canada.
L BouchardDepartment of Biochemistry, Université de Sherbrooke, Sherbrooke, QC, Canada.
Université de Sherbrooke · CAMcMaster University · CA

Funding

CIHR PJT-152989
6 · The paper itself

Abstract

Studies have linked maternal pre-pregnancy obesity and hyperglycaemia with metabolic and neurodevelopmental complications in childhood. DNA methylation (DNAm) might enable foetal adaptations to environmental adversities through important gene loci.

Indexed as

Body Mass IndexChild DevelopmentDNA MethylationAdultCell Adhesion Molecules, NeuronalChild, PreschoolEpigenesis, GeneticFemaleGPI-Linked ProteinsHumansInfant, NewbornMaleNeuropsychological TestsPlacentaPregnancyCell Adhesion Molecules, NeuronalGPI-Linked ProteinsNEGR1 protein, humanchildhood developmentDOHaDEpigeneticsfoetal programmingobesitySDQ

Identifiers

PMID31510847
PMCPMC7028343
OpenAlexW2972528885

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.