ArticleCanadian journal of psychiatry. Revue canadienne de psychiatrie2019
FKBP5 Genotype Linked to Combined PTSD-Depression Symptom in Chinese Earthquake Survivors.
Article in Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
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- Expanding the Scope: In-depth Review of Interaction in Regression Models.Annals of clinical epidemiology · 2024Article
- The association of FKBP5 polymorphisms with the severity of depressive disorder in patients with methamphetamine use disorders.Frontiers in psychiatry · 2023Article
- Role of FKBP5 and its genetic mutations in stress-induced psychiatric disorders: an opportunity for drug discovery.Frontiers in psychiatry · 2023Review
- Methylation of genes and regulation of inflammatory processes on emotional response in young adults with alcoholic parents.Brain, behavior, & immunity - health · 2022Article
- Association of SNPs in the FK-506 binding protein (FKBP5) gene among Han Chinese women with polycystic ovary syndrome.BMC medical genomics · 2022Article
- TheFrontiers in psychiatry · 2021Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPost-traumatic stress disorder (PTSD) and depression are common mental disorders in individuals experiencing traumatic events. To date, few studies have studied the relationship between genetic basis and phenotypic heterogeneity of traumatized individuals. The present study examined the effects of four
methodsA total of 1,140 adults who experienced the 2008 Wenchuan earthquake participated in our study. Earthquake-related trauma, PTSD, and depressive symptoms were measured using standard psychometric instruments. The four
resultsAfter adjusting for covariates, the main and gene-environment interaction effects of rs9470080 were all significant when the combined PTSD-depression group was compared with the low symptoms, predominantly depression and predominantly PTSD groups. rs9470080 TT genotype carriers had a higher risk of developing high co-occurring PTSD and depression symptoms than the C allele carriers. However, when trauma exposure was severe, the TT genotype carriers and C allele carriers did not differ in the risk of developing high co-occurring PTSD and depressive symptoms. The other three SNPs demonstrated no significant effects. Moreover, the rs3800373-rs9296158-rs1360780-rs9470080 haplotype A-G-C-T was found significantly associated with combined PTSD-depression symptoms.
conclusionOur findings support the genetic basis of phenotypic heterogeneity in people exposed to trauma. Furthermore, the results reveal the possibility that the variants of
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