ArticleMicroorganisms2019
Microbiota, Microbial Metabolites, and Barrier Function in A Patient with Anorexia Nervosa after Fecal Microbiota Transplantation.
Article in Microorganisms, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Anorexia nervosa and microbiota: systematic review and critical appraisal.Eating and weight disorders : EWD · 2023Pooled it
- A systematic review on the role of microbiota in the pathogenesis and treatment of eating disorders.European psychiatry : the journal of the Association of European Psychiatrists · 2020Pooled it
- Encapsulated faecal microbiota transfer in young women with anorexia nervosa: an open-label feasibility pilot trial.Nature communications · 2025Trial
- Gut microbiota contributions to anorexia nervosa pathogenesis: insights from the activity-based anorexia model.NPJ biofilms and microbiomes · 2026Article
- A Refined Method for Fecal Microbiota Transplantation Using Nutella.Clinical and translational science · 2026Article
- From gut to brain: effects of fecal microbiota transplants from humans to rats on hippocampal gene regulation - a study on anorexia nervosa.Translational psychiatry · 2026Article
- Protocol for a pilot feasibility randomised controlled trial of fecal microbiota transplantation for adolescent anorexia nervosa.BMJ open · 2026Article
- Impact of a single fecal microbiome transplantation in adult women with anorexia nervosa: an open-label feasibility pilot trial.Nature communications · 2026Article
- Microbiome and metabolic disruption in acute vs. severe and enduring anorexia nervosa.NPJ biofilms and microbiomes · 2025Article
- From shared mechanisms to treatment gaps: a review of the comorbidity between eating disorders and PTSD.Journal of eating disorders · 2025Review
- Exploring the Link Between the Gut Microbiota and Epigenetic Factors in Anorexia Nervosa.Brain and behavior · 2025Review
- Antibiotic-Induced Microbial Dysbiosis Worsened Outcomes in the Activity-Based Anorexia Model.The International journal of eating disorders · 2025Article
- Investigating fecal microbiota transplants from individuals with anorexia nervosa in antibiotic-treated mice using a cross-over study design.Journal of eating disorders · 2025Article
- Harnessing precision nutrition to individualize weight restoration in anorexia nervosa.Journal of eating disorders · 2025Review
- Efficacy and safety of faecal microbiota transplantation (FMT) in recurrentPrzeglad gastroenterologiczny · 2025Article
- Relationship of Genetic Polymorphisms and Microbial Composition with Binge Eating Disorder: A Systematic Review.Healthcare (Basel, Switzerland) · 2024Review
- Eating disorders: are gut microbiota to blame?Trends in molecular medicine · 2024Article
- Gut Microbiome Changes in Anorexia Nervosa: A Comprehensive Review.Pathophysiology : the official journal of the International Society for Pathophysiology · 2024Review
- Fecal microbiota transplantation alleviates cognitive impairment by improving gut microbiome composition and barrier function in male rats of traumatic brain injury following gas explosion.Frontiers in microbiology · 2024Article
- Fresh Washed Microbiota Transplantation Alters Gut Microbiota Metabolites to Ameliorate Sleeping Disorder Symptom of Autistic Children.Journal of microbiology (Seoul, Korea) · 2023Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
The change in the gut microbiome and microbial metabolites in a patient suffering from severe and enduring anorexia nervosa (AN) and diagnosed with small intestinal bacterial overgrowth syndrome (SIBO) was investigated. Microbial gut dysbiosis is associated with both AN and SIBO, and therefore gut microbiome changes by serial fecal microbiota transplantation (FMT) is a possible therapeutic modality. This study assessed the effects of FMT on gut barrier function, microbiota composition, and the levels of bacterial metabolic products. The patient treatment with FMT led to the improvement of gut barrier function, which was altered prior to FMT. Very low bacterial alpha diversity, a lack of beneficial bacteria, together with a great abundance of fungal species were observed in the patient stool sample before FMT. After FMT, both bacterial species richness and gut microbiome evenness increased in the patient, while the fungal alpha diversity decreased. The total short-chain fatty acids (SCFAs) levels (molecules presenting an important source of energy for epithelial gut cells) gradually increased after FMT. Contrarily, one of the most abundant intestinal neurotransmitters, serotonin, tended to decrease throughout the observation period. Overall, gut microbial dysbiosis improvement after FMT was considered. However, there were no signs of patient clinical improvement. The need for an in-depth analysis of the donor´s stool and correct selection pre-FMT is evident.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.