ArticleInternational journal of molecular sciences2019
Mechanisms of Stress-Induced Spermatogenesis Impairment in Male Rats Following Unpredictable Chronic Mild Stress (uCMS).
Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Paternal Nicotine/Ethanol/Caffeine Mixed Exposure Induces Offspring Rat Dysplasia and Its Potential "GC-IGF1" Programming Mechanism.International journal of molecular sciences · 2022Pooled it
- Chronic stress drives oligoasthenozoospermia via gut microbiota-vitamin-Sting1/Slc9c2 axis.Nature communications · 2026Article
- Psychological Stress and Male Infertility: Oxidative Stress as the Common Downstream Pathway.Biomedicines · 2026Review
- Unveiling novel insights into the role and characteristics of sperm heat shock protein 70 in indigenous Donggala bulls: implications for molecular-based motility markers.Archives animal breeding · 2026Article
- Protective Effects ofLife (Basel, Switzerland) · 2025Article
- Chronic Variable Stress May Induce Apoptosis in the Testis and Epididymal Sperm of Young Male Rats.Biology · 2025Article
- Beta(β)-sitosterol attenuates Chronic Unpredictable Stress (CUS) Induced Testicular Damage in the Experimental Rat Model.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- The consequences of climate change and male reproductive health: A review of the possible impact and mechanisms.Biochemistry and biophysics reports · 2025Review
- Prevention of seminal vesicle damage byPharmaceutical biology · 2023Article
- SARS-CoV-2 and male infertility: from short- to long-term impacts.Journal of endocrinological investigation · 2023Review
- The Protective Effect of Oxitard on Sperm Function and Antioxidant Status in Rats Exposed to Swimming Stress.Cureus · 2023Article
- Effects of tadalafil on sexual behavior of male rats induced by chronic unpredictable mild stress.Sexual medicine · 2023Article
- Microbiome-Metabolome Reveals the Contribution of the Gut-Testis Axis to Sperm Motility in Sheep (Animals : an open access journal from MDPI · 2023Article
- Social isolation exacerbates acute ozone inhalation induced pulmonary and systemic health outcomes.Toxicology and applied pharmacology · 2022Article
- Activating PPARβ/δ Protects against Endoplasmic Reticulum Stress-Induced Astrocytic Apoptosis via UCP2-Dependent Mitophagy in Depressive Model.International journal of molecular sciences · 2022Article
- Protective effects of ThaiJournal of traditional and complementary medicine · 2022Article
- Betaine attenuate chronic restraint stress-induced changes in testicular damage and oxidative stress in male mice.Reproductive biology and endocrinology : RB&E · 2022Article
- Article
- Spermatozoa Develop Molecular Machinery to Recover From Acute Stress.Frontiers in endocrinology · 2022Article
- Nociceptor Overexpression of NaThe journal of pain · 2021Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
The negative association between psychological stress and male fertility has been known for many years. This study was aimed at (i) identifying spermatogenesis impairment induced by psychological stress in rats and (ii) exploring the role of glucocorticoid receptor (GR) signaling in these adverse effects (if they exist). Male Sprague Dawley rats were exposed to a six-week period of unpredictable chronic mild stress (uCMS) along with cotreatment of GR antagonist RU486 (1 mg/kg/day). Testicular damage was assessed by testicular pathological evaluation, epididymal sperm concentration, serum testosterone levels, testicular apoptotic cell measurements, and cell cycle progression analyses. Rats in the uCMS group had decreased levels of serum testosterone and decreased epididymal sperm concentration. The uCMS-treated rats also had decreased numbers of spermatids and increased levels of apoptotic seminiferous tubules; additionally, cell cycle progression of spermatogonia was arrested at the G
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.