Evidence map›Paper›PMID 31510083›Full record

ArticleJournal of clinical medicine2019

Correlation between Choriocapillaris Density and Retinal Sensitivity in Stargardt Disease.

Rodolfo Mastropasqua, Alfonso Senatore, Luca Di Antonio, Marta Di Nicola, Michele Marchioni, Fabiana Perna, Filippo Amore, Enrico Borrelli, Chiara De Nicola, Paolo Carpineto and 1 more

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Widefield Swept Source OCTA in Retinitis Pigmentosa.Diagnostics (Basel, Switzerland) · 2020
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rodolfo MastropasquaOphthalmology Clinic, University of Marche, 60126 Ancona, Italy.
Alfonso SenatoreOphthalmology Clinic, Department of Medicine and Science of Ageing, University G. D'Annunzio Chieti-Pescara, via dei Vestini 31, 66100 Chieti, Italy. doctor_alf@hotmail.it.
Luca Di AntonioOphthalmology Clinic, Department of Medicine and Science of Ageing, University G. D'Annunzio Chieti-Pescara, via dei Vestini 31, 66100 Chieti, Italy.
Marta Di NicolaDepartment of Medical, Oral and Biotechnological Sciences, Laboratory of Biostatistics, University "G. d'Annunzio" Chieti-Pescara, via dei Vestini 31, 66100 Chieti, Italy.
Michele MarchioniDepartment of Medical, Oral and Biotechnological Sciences, Laboratory of Biostatistics, University "G. d'Annunzio" Chieti-Pescara, via dei Vestini 31, 66100 Chieti, Italy.
Fabiana PernaNational Center for Services and Research for the Prevention of Blindness and Visual Rehabilitation of the Visually Impaired, 00100 Rome, Italy.
Filippo AmoreNational Center for Services and Research for the Prevention of Blindness and Visual Rehabilitation of the Visually Impaired, 00100 Rome, Italy.
Enrico BorrelliOphthalmology Department, San Raffaele University Hospital, 20132 Milan, Italy.
Chiara De NicolaOphthalmology Clinic, Department of Medicine and Science of Ageing, University G. D'Annunzio Chieti-Pescara, via dei Vestini 31, 66100 Chieti, Italy.
Paolo CarpinetoOphthalmology Clinic, Department of Medicine and Science of Ageing, University G. D'Annunzio Chieti-Pescara, via dei Vestini 31, 66100 Chieti, Italy.
Lisa TotoOphthalmology Clinic, Department of Medicine and Science of Ageing, University G. D'Annunzio Chieti-Pescara, via dei Vestini 31, 66100 Chieti, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this work was to characterize the choriocapillaris (CC) in patients with Stargardt disease (STGD) using the swept source widefield optical coherence tomography angiography (SS WF OCTA) and to compare CC perfusion density to retinal sensitivity, analyzed using microperimetry (MP). This cross-sectional study included 9 patients (18 eyes) with STGD and central CC atrophy (stage 3 STGD). The CC was analyzed using SS WF OCTA and areas of different CC impairment were quantified and correlated with retinal sensitivity analyzed using MP. The main outcome measures were the percent perfused choriocapillaris area (PPCA), retinal sensitivity, and correlation between PPCA and retinal sensitivity. Seventeen eyes of 9 patients suffering from stage 3 STGD were analyzed. SS WF OCTA revealed a vascular rarefaction in central atrophic zones and a near atrophy halo of choriocapillaris impairment. In all eyes were noticed a central atrophy (CA) area with absolute absence of CC that corresponded to 0 dB points at MP, a near atrophy (NA) zone of PPCA impairment that included points with decreased sensitivity at MP and a distant from atrophy (DA) zone with higher PPCA and retinal sensitivity values. The mean difference of PPCA and retinal sensitivity between NA and CA and DA and CA was statistical significantly different (

Indexed as

choriocapillarismicroperimetryOCTAretinaStargardt disease

Identifiers

PMID31510083
PMCPMC6780313

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.