An Isotopic Ratio Outlier Analysis Approach for Global Metabolomics of Biosynthetically Talented Actinomycetes.

Jordan Carey, Thanh Nguyen, Jennifer Korchak, Christopher Beecher, Felice de Jong, Amy L Lane

Open access · goldAbstract read

In one paragraph

Article in Metabolites, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.2field-weighted citation impact, top 42% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

Quantitative Bioreactor Monitoring of Intracellular Bacterial Metabolites inACS omega · 2021
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jordan CareyChemistry Department, University of North Florida, Jacksonville, FL 32224, USA.

Thanh NguyenChemistry Department, University of North Florida, Jacksonville, FL 32224, USA.

Jennifer KorchakChemistry Department, University of North Florida, Jacksonville, FL 32224, USA.

Christopher BeecherIROA Technologies, Ann Arbor, MI 48105, USA.ORCID 0000-0003-4934-7278

Felice de JongIROA Technologies, Ann Arbor, MI 48105, USA.

Amy L LaneChemistry Department, University of North Florida, Jacksonville, FL 32224, USA. amy.lane@unf.edu.ORCID 0000-0002-8386-364X

University of North Florida · US

Funding

University of Florida Southeast Center for Integrated Metabolomics Pilot & Feasibility Grant N/A

6 · The paper itself

Abstract

Actinomycetes are powerhouses of natural product biosynthesis. Full realization of this biosynthetic potential requires approaches for recognizing novel metabolites and determining mediators of metabolite production. Herein, we develop an isotopic ratio outlier analysis (IROA) ultra-high performance liquid chromatography-mass spectrometry (UHPLC/MS) global metabolomics strategy for actinomycetes that facilitates recognition of novel metabolites and evaluation of production mediators. We demonstrate this approach by determining impacts of the iron chelator 2,2'-bipyridyl on the

Indexed as

actinomycetediketopiperazineglobal metabolomicsisotopic ratio outlier analysisliquid chromatography-mass spectrometrynatural productsecondary metabolitesiderophore

Identifiers

PMID31510039

DOI10.3390/metabo9090181

PMCPMC6780544

OpenAlexW2972617752

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.