Evidence map›Paper›PMID 31509999›Full record

ArticleSensors (Basel, Switzerland)2019

Towards Real-Time Prediction of Freezing of Gait in Patients With Parkinson's Disease: Addressing the Class Imbalance Problem.

Nader Naghavi, Aaron Miller, Eric Wade

Registry-linked trialAbstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04274478 (Biofeedback to Reduce Freezing of Gait in Parkinson Patients - Ceriter/Insole Parkinson Disease), which is not on this map. Cited by 16 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04274478 naterminatednot on this map

Biofeedback to Reduce Freezing of Gait in Parkinson Patients - Ceriter/Insole Parkinson Disease (IPD)-1

TypeinterventionalSponsorCeriter Nederland BVRan2019 to 2021Enrolled13ConditionsParkinson DiseaseArmsAuditive cueing
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  8. Detection and prediction of freezing of gait with wearable sensors in Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nader NaghaviDepartment of Mechanical, Aerospace and Biomedical Engineering, University of Tennessee, Knoxville, TN 37996, USA. nnaghavi@utk.edu.ORCID 0000-0002-3273-7213
Aaron MillerDepartment of Mechanical, Aerospace and Biomedical Engineering, University of Tennessee, Knoxville, TN 37996, USA. amill106@utk.edu.ORCID 0000-0001-5527-420X
Eric WadeDepartment of Mechanical, Aerospace and Biomedical Engineering, University of Tennessee, Knoxville, TN 37996, USA. erwade@utk.edu.ORCID 0000-0002-7228-2495

Funding

National Science Foundation 1502242
6 · The paper itself

Abstract

Freezing of gait (FoG) is a common motor symptom in patients with Parkinson's disease (PD). FoG impairs gait initiation and walking and increases fall risk. Intelligent external cueing systems implementing FoG detection algorithms have been developed to help patients recover gait after freezing. However, predicting FoG before its occurrence enables preemptive cueing and may prevent FoG. Such prediction remains challenging given the relative infrequency of freezing compared to non-freezing events. In this study, we investigated the ability of individual and ensemble classifiers to predict FoG. We also studied the effect of the ADAptive SYNthetic (ADASYN) sampling algorithm and classification cost on classifier performance. Eighteen PD patients performed a series of daily walking tasks wearing accelerometers on their ankles, with nine experiencing FoG. The ensemble classifier formed by Support Vector Machines, K-Nearest Neighbors, and Multi-Layer Perceptron using bagging techniques demonstrated highest performance (F1 = 90.7) when synthetic FoG samples were added to the training set and class cost was set as twice that of normal gait. The model identified 97.4% of the events, with 66.7% being predicted. This study demonstrates our algorithm's potential for accurate prediction of gait events and the provision of preventive cueing in spite of limited event frequency.

Indexed as

Computer SystemsAccelerometryAgedAlgorithmsFemaleGaitHumansMaleParkinson DiseaseSignal Processing, Computer-AssistedADASYNcost of classificationdata synthesisensemble classifierfreezing of gaitParkinson’s diseasewearable sensors

Identifiers

PMID31509999
PMCPMC6767263

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.