ReviewAlcohol and alcoholism (Oxford, Oxfordshire)2019
From Pleasure to Pain, and Back Again: The Intricate Relationship Between Alcohol and Nociception.
Review in Alcohol and alcoholism (Oxford, Oxfordshire), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 58 citations in OpenAlex.
- Prevalence of Chronic Pain and Associated Factors Among Nursing Students in Heilongjiang Province, China: A Cross-Sectional Study.Nursing open · 2026Article
- Mitochondrial dysfunction at the intersection of alcohol use disorder and chronic pain.Function (Oxford, England) · 2026Review
- The analgesic effect of neuropeptide S (NPS) in alcohol-dependent male and female rats.Alcohol (Fayetteville, N.Y.) · 2026Article
- Substance use frequency and associations with chronic pain among a cohort of people who inject drugs in Montreal, Canada.Canadian journal of pain = Revue canadienne de la douleur · 2026Article
- A conceptual framework for the intersection of hyperalgesia and hyperkatifeia in alcohol addiction.Alcohol (Fayetteville, N.Y.) · 2025Review
- Adaptive Serum Biochemistry Responses to Ethanol Administration in a Mouse Model: Implications for Metabolic Regulation Under Analgesia.Molecules (Basel, Switzerland) · 2025Article
- Prior adolescent oxycodone exposure enhances pain sensitivity following chronic intermittent ethanol in adult female mice.Physiology & behavior · 2025Article
- Persistent inflammation does not promote aversion-resistant binge-like alcohol drinking in rats.Alcohol (Fayetteville, N.Y.) · 2025Article
- Sigma‑2 Receptor/Transmembrane Protein 97 in Pain Modulation: Tracing Historical Roots and Current Research Directions.ACS pharmacology & translational science · 2025Review
- Intersection of alcohol use, pain symptoms, and negative affect in total knee arthroplasty patients and people with HIV.The journal of pain · 2025Article
- Alcohol Consumption Modulates the Development of Chronic Pain in COVID-19 Patients: A Network Meta-Analysis.ACS pharmacology & translational science · 2025Article
- Parabrachial calcitonin gene-related peptide neurons sex-specifically modulate behavior in anxiety assays during alcohol withdrawal.Frontiers in pharmacology · 2025Article
- Neural responses to stress and alcohol cues in individuals with pain with and without alcohol use disorder.Addiction biology · 2024Article
- Let's focus on the insula in addiction: A refined anatomical exploration of insula in severe alcohol and cocaine use disorders.European psychiatry : the journal of the Association of European Psychiatrists · 2024Article
- Emotional and cognitive influences on alcohol consumption in middle-aged and elderly Tanzanians: a population-based study.Scientific reports · 2024Article
- Sub-anesthetic dose of esketamine decreases postoperative opioid self-administration after spine surgery: a retrospective cohort analysis.Scientific reports · 2024Article
- Within and Beyond the Binary: Sex and Gender Differences in Pain and Alcohol Use Disorder.Current addiction reports · 2024Article
- Heavy Alcohol Use and HIV Outcomes: The Moderating Role of Pain.AIDS and behavior · 2024Article
- Alcohol use and the pain system.Advances in drug and alcohol research · 2024Review
- Long-lasting mechanical hypersensitivity and CRF receptor type-1 neuron activation in the BNST following adolescent ethanol exposure.Alcohol, clinical & experimental research · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
aimsA close and bidirectional relationship between alcohol consumption and pain has been previously reported and discussed in influential reviews. The goal of the present narrative review is to provide an update on the developments in this field in order to guide future research objectives.
methodsWe evaluated both epidemiological and neurobiological literature interrogating the relationship between alcohol use and pain for the presence of significant effects. We outlined studies on interactions between alcohol use and pain using both self-reports and objective experimental measures and discussed potential underlying mechanisms of these interactions.
resultsEpidemiological, preclinical and clinical literature point to three major interactions between alcohol use and pain: (a) alcohol use leading to hyperalgesia, (b) alcohol use moderating pain and hyperalgesia and (c) chronic pain as a risk factor predisposing to alcohol relapse. Neurobiological studies using animal models to assess these interactions have transitioned from mostly involuntary modes of experimenter-controlled alcohol administration to self-administration procedures, and increasingly indicate that neuronal circuits implicated in both withdrawal and anticipation stages of alcohol use disorder also have a role in chronic pain. Mechanistically, alterations in GABA, glutamate, the corticotropin-releasing factor system, endogenous opioids and protein kinase C appear to play crucial roles in this maladaptive overlap.
conclusionsMany of the principles explaining the interactions between alcohol and pain remain on a strong foundation, but continuing progress in modeling these interactions and underlying systems will provide a clearer basis for understanding, and ultimately treating, the damaging aspects of this interaction.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.