ReviewHormone research in paediatrics2019
Current Insights into the Role of the Growth Hormone-Insulin-Like Growth Factor System in Short Children Born Small for Gestational Age.
Review in Hormone research in paediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 41 citations in OpenAlex.
- Growth Hormone Therapy in Children Born Small for Gestational Age with Persistent Short Stature: Lessons Learned from Real-World International Databases and Directions for Future Research.Hormone research in paediatrics · 2026Review
- IGFBP3 repression driven by inflammation links air pollution to placental and developmental defects.EMBO molecular medicine · 2026Article
- Expression and Methylation of Insulin-Like Growth Factor Binding Protein-1 Gene in Cord Blood of Intrauterine Growth Restricted Neonates.Indian journal of pediatrics · 2026Article
- Postnatal Growth Patterns and Deviations in Singleton and Twin Infants: A Prospective Cohort Study on Infants Appropriate and Small for Gestational Age.Pediatric discovery · 2025Article
- Insulin-like growth factor binding protein-3 (IGFBP-3): a biomarker of coronary artery disease induced myocardial ischaemia.European heart journal open · 2025Article
- Inadequate linear catch-up growth in children born small for gestational age: Influencing factors and underlying mechanisms.Reviews in endocrine & metabolic disorders · 2024Review
- Vitamin D status and VDR gene polymorphisms in patients with growth hormone deficiency: A case control Tunisian study.Heliyon · 2024Article
- Whole-Exome and Transcriptome Sequencing Expands the Genotype of Majewski Osteodysplastic Primordial Dwarfism Type II.International journal of molecular sciences · 2023Article
- Difficulties in Interpreting IGF-1 Levels in Short Stature Children Born Small for Gestational Age (SGA) Treated with Recombinant Human Growth Hormone (rhGH) Based on Data from Six Clinical Centers in Poland.Journal of clinical medicine · 2023Article
- The Variability of Growth and Puberty in Growth Hormone-treated Children Born Small for Gestational Age.The Journal of clinical endocrinology and metabolism · 2022Article
- Genetics and voice production in childhood and adolescence - a review.International journal of pediatrics & adolescent medicine · 2022Article
- Growth hormone treatment does not to lead to insulin resistance nor excessive rise in IGF-1 levels, while improving height in patients small for gestational age A long-term observational study.Clinical endocrinology · 2022Observational
- Bioactive peptides identification and nutritional status ameliorating properties on malnourished rats of combined eel and soy-based tempe flour.Frontiers in nutrition · 2022Article
- IGF1R, IGFALS, and IGFBP3 gene copy number variations in a group of non-syndromic Egyptian short children.Journal, genetic engineering & biotechnology · 2021Article
- New Horizons in Short Children Born Small for Gestational Age.Frontiers in pediatrics · 2021Review
- Disorders caused by genetic defects associated with GH-dependent genes: PAPPA2 defects.Molecular and cellular endocrinology · 2020Review
- Adult-Onset Diseases in Low Birth Weight Infants: Association with Adipose Tissue Maldevelopment.Journal of atherosclerosis and thrombosis · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe reason for the insufficient catch-up growth seen in 10% of children born small for gestational age (SGA) is poorly understood. Disturbances in the growth hormone (GH) - insulin-like growth factor (IGF) axis might underlie this failure to show sufficient catch-up growth.
conclusionThis review summarizes insights gained in the molecular and (epi) genetic mechanisms of the GH-IGF axis in short children born SGA. The most notable anomalies of the IGF system are the lowered IGF-I levels in both cord blood and the placenta, and the increased expression of IGF-binding proteins (IGFBP)-1 and IGFBP-2, which inhibit IGF-I, in the placenta of SGA neonates. These observations suggest a decreased bioactivity of IGF-I in utero. IGF-I levels remain reduced in SGA children with short stature, as well as IGFBP-3 and acid-labile subunit levels. Proteolysis of IGFBP-3 appears to be increased.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.