ReviewNeuroscience and biobehavioral reviews2019
The study of active avoidance: A platform for discussion.
Review in Neuroscience and biobehavioral reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed.
- Early adversity promotes adolescent avoidance behavior by enhancing prefrontal-amygdala communication through CRHbioRxiv : the preprint server for biology · 2026Article
- Article
- Neural basis of social hierarchy across species.Nature reviews. Neuroscience · 2026Review
- Mild concussion impairs extinction of avoidance and alters respective brain circuits in male rats.Experimental neurology · 2026Article
- Male Sapap3 knockout mice show threat bias under conflict during platform-mediated avoidance task: effects of extinction with response prevention and implications for obsessive compulsive disorder.Translational psychiatry · 2026Article
- Rats use darting as a strategy to navigate between reward and safety during platform-mediated active avoidance under different social contexts.bioRxiv : the preprint server for biology · 2026Article
- The behavioral and neural architecture of observational active avoidance is shaped by demonstrator experience and observer sex.Scientific reports · 2026Article
- Darting during platform-mediated avoidance in male and female rats is spatially organized between reward and safety locations.Frontiers in behavioral neuroscience · 2026Article
- Neurobiology of resilience to early life stress.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Female rats adopt a safety-first strategy in a high-conflict platform mediated avoidance task.Frontiers in behavioral neuroscience · 2026Article
- Dopaminergic projections to the prefrontal cortex are critical for rapid threat avoidance learning.Current biology : CB · 2025Article
- Article
- Developmentally distinct architectures in top-down pathways controlling threat avoidance.Nature neuroscience · 2025Article
- Generalization and extinction of platform-mediated avoidance in male and female rats.Scientific reports · 2025Article
- Intersect between brain mechanisms of conditioned threat, active avoidance, and reward.Communications psychology · 2025Review
- Modifying the platform-mediated avoidance task: A new protocol to study active avoidance within a social context in rats.PloS one · 2025Article
- Behavioral and Brain Mechanisms of Active Avoidance and Their Relevance to Anxiety Disorders.Current topics in behavioral neurosciences · 2025Review
- The Organization of Anxiety Symptoms Along the Threat Imminence Continuum.Current topics in behavioral neurosciences · 2025Review
- Social context modulates active avoidance: Contributions of the anterior cingulate cortex in male and female rats.Neurobiology of stress · 2025Article
- Comparative Physiology and Morphology of BLA-Projecting NBM/SI Cholinergic Neurons in Mouse and Macaque.The Journal of comparative neurology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Traditional active avoidance tasks have advanced the field of aversive learning and memory for decades and are useful for studying simple avoidance responses in isolation; however, these tasks have limited clinical relevance because they do not model several key features of clinical avoidance. In contrast, platform-mediated avoidance (PMA) more closely resembles clinical avoidance because the response i) is associated with an unambiguous safe location, ii) is not associated with an artificial termination of the warning signal, and iii) is associated with a decision-based appetitive cost. Recent findings on the neuronal circuits of PMA have confirmed that amygdala-striatal circuits are essential for avoidance. In PMA, however, the prelimbic cortex facilitates the avoidance response early during the warning signal, perhaps through disinhibition of the striatum. Future studies on avoidance should account for additional factors such as sex differences and social interactions that will advance our understanding of maladaptive avoidance contributing to neuropsychiatric disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.