ArticleCell reports2019
Similarity and Strength of Glomerular Odor Representations Define a Neural Metric of Sniff-Invariant Discrimination Time.
Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Synaptic Inhibition in the Accessory Olfactory Bulb Regulates Pheromone Location Learning and Memory.FASEB bioAdvances · 2026Article
- Odor identity decoding by mitral/tufted cells in the olfactory bulb from large-scale pooled datasets.iScience · 2026Article
- High-Accuracy Detection of Odor Presence from Olfactory Bulb Local Field Potentials via Deep Neural Networks.Sensors (Basel, Switzerland) · 2026Article
- Mouse olfactory system acts as anemo-detector and anemo-discriminator.Science advances · 2025Article
- Alpha-synuclein pathology and Parkinson's disease-related olfactory dysfunctions: an update on preclinical models and therapeutic approaches.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Review
- Optimized laser speckle-based imaging system and methods for deep tissue cerebral blood flow imaging in small rodents.Neurophotonics · 2025Article
- Odor representation and coding by the mitral/tufted cells in the olfactory bulb.Journal of Zhejiang University. Science. B · 2024Review
- Long COVID: From olfactory dysfunctions to viral Parkinsonism.World journal of otorhinolaryngology - head and neck surgery · 2024Article
- Perceptual learning deficits mediated by somatostatin releasing inhibitory interneurons of olfactory bulb in an early life stress mouse model.Molecular psychiatry · 2023Article
- Active smelling in the American cockroach.The Journal of experimental biology · 2023Article
- Knockout of angiotensin converting enzyme-2 receptor leads to morphological aberrations in rodent olfactory centers and dysfunctions associated with sense of smell.Frontiers in neuroscience · 2023Article
- Persistent olfactory learning deficits during and post-COVID-19 infection.Current research in neurobiology · 2023Article
- Article
- Multimodal learning of pheromone locations.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Olfactory bulb granule cells: specialized to link coactive glomerular columns for percept generation and discrimination of odors.Cell and tissue research · 2021Article
- Article
- Local Postsynaptic Signaling on Slow Time Scales in Reciprocal Olfactory Bulb Granule Cell Spines Matches Asynchronous Release.Frontiers in synaptic neuroscience · 2020Article
- An increase in neural stem cells and olfactory bulb adult neurogenesis improves discrimination of highly similar odorants.The EMBO journal · 2019Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
Abstract
The olfactory environment is first represented by glomerular activity patterns in the olfactory bulb. It remains unclear how these representations intersect with sampling behavior to account for the time required to discriminate odors. Using different chemical classes, we investigate glomerular representations and sniffing behavior during olfactory decision-making. Mice rapidly discriminate odorants and learn to increase sniffing frequency at a fixed latency after trial initiation, independent of odor identity. Relative to the increase in sniffing frequency, monomolecular odorants are discriminated within 10-40 ms, while binary mixtures require an additional 60-70 ms. Intrinsic imaging of glomerular activity in anesthetized and awake mice reveals that Euclidean distance between activity patterns and the time needed for discriminations are anti-correlated. Therefore, the similarity of glomerular patterns and their activation strengths, rather than sampling behavior, define the extent of neuronal processing required for odor discrimination, establishing a neural metric to predict olfactory discrimination time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.