ArticleCell reports2019
Control of Intestinal Cell Fate by Dynamic Mitotic Spindle Repositioning Influences Epithelial Homeostasis and Longevity.
Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 53 citations in OpenAlex.
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- Highly regenerative species-specific genes improve age-associated features in the adult Drosophila midgut.BMC biology · 2024Article
- Inter-cell type interactions that control JNK signaling in the Drosophila intestine.Nature communications · 2024Article
- Chitosan oligosaccharide improves intestinal homeostasis to achieve the protection for the epithelial barrier of femaleMicrobiology spectrum · 2024Article
- A feedback loop that drives cell death and proliferation and its defect in intestinal stem cells.Life science alliance · 2024Article
- Drosophila activins adapt gut size to food intake and promote regenerative growth.Nature communications · 2024Article
- JAK/STAT signaling regulated intestinal regeneration defends insect pests against pore-forming toxins produced by Bacillus thuringiensis.PLoS pathogens · 2024Article
- Old and newly synthesized histones are asymmetrically distributed in Drosophila intestinal stem cell divisions.EMBO reports · 2023Article
- Apical-basal polarity precisely determines intestinal stem cell number by regulating Prospero threshold.Cell reports · 2023Article
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- An improved organ explant culture method reveals stem cell lineage dynamics in the adulteLife · 2022Article
- Insect Gut Regeneration.Cold Spring Harbor perspectives in biology · 2022Review
- Non-canonical Wnt signaling promotes directed migration of intestinal stem cells to sites of injury.Nature communications · 2021Article
- JNK Signaling inInternational journal of molecular sciences · 2021Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Tissue homeostasis depends on precise yet plastic regulation of stem cell daughter fates. During growth, Drosophila intestinal stem cells (ISCs) adjust fates by switching from asymmetric to symmetric lineages to scale the size of the ISC population. Using a combination of long-term live imaging, lineage tracing, and genetic perturbations, we demonstrate that this switch is executed through the control of mitotic spindle orientation by Jun-N-terminal kinase (JNK) signaling. JNK interacts with the WD40-repeat protein Wdr62 at the spindle and transcriptionally represses the kinesin Kif1a to promote planar spindle orientation. In stress conditions, this function becomes deleterious, resulting in overabundance of symmetric fates and contributing to the loss of tissue homeostasis in the aging animal. Restoring normal ISC spindle orientation by perturbing the JNK/Wdr62/Kif1a axis is sufficient to improve intestinal physiology and extend lifespan. Our findings reveal a critical role for the dynamic control of SC spindle orientation in epithelial maintenance.
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Registered trials
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