ArticleCell reports2019
A Midbrain Circuit that Mediates Headache Aversiveness in Rats.
Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Early life stress induces brain-wide electrical network predisposition to migraine.The journal of headache and pain · 2026Article
- Review
- The dorsal column nuclei encode and transmit the network signatures of mechanical allodynia.Cell reports · 2025Article
- Brain circuits that regulate social behavior.Molecular psychiatry · 2025Review
- Convergent state-control of endogenous opioid analgesia.bioRxiv : the preprint server for biology · 2025Article
- Advances of neuroimaging findings in medication overuse headache.Frontiers in neuroscience · 2025Review
- Acute Ongoing Nociception Delays Recovery of Consciousness from Sevoflurane Anesthesia via a Midbrain Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Separation of Channels Subserving Approach and Avoidance/Escape at the Level of the Basal Ganglia and Related Brainstem Structures.Current neuropharmacology · 2024Review
- Impaired Ventrolateral Periaqueductal Gray-Ventral Tegmental area Pathway Contributes to Chronic Pain-Induced Depression-Like Behavior in Mice.Molecular neurobiology · 2023Article
- Neuropeptides Modulate Feeding via the Dopamine Reward Pathway.Neurochemical research · 2023Review
- Enlarged perivascular spaces in patients with migraine: a case-control study based on 3T MRI.Annals of clinical and translational neurology · 2023Article
- Converging circuits between pain and depression: the ventral tegmental area as a therapeutic hub.Frontiers in pharmacology · 2023Review
- Pharmacological modulation of ventral tegmental area neurons elicits changes in trigeminovascular sensory processing and is accompanied by glycemic changes: Implications for migraine.Cephalalgia : an international journal of headache · 2022Article
- Engaging endogenous opioid circuits in pain affective processes.Journal of neuroscience research · 2022Review
- Brain circuits for pain and its treatment.Science translational medicine · 2021Review
- Pain induces adaptations in ventral tegmental area dopamine neurons to drive anhedonia-like behavior.Nature neuroscience · 2021Article
- Neuropeptide and cytokine regulation of pain in the context of substance use disorders.Neuropharmacology · 2020Review
- Endogenous opioid peptides in the descending pain modulatory circuit.Neuropharmacology · 2020Review
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Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Migraines are a major health burden, but treatment is limited because of inadequate understanding of neural mechanisms underlying headache. Imaging studies of migraine patients demonstrate changes in both pain-modulatory circuits and reward-processing regions, but whether these changes contribute to the experience of headache is unknown. Here, we demonstrate a direct connection between the ventrolateral periaqueductal gray (vlPAG) and the ventral tegmental area (VTA) that contributes to headache aversiveness in rats. Many VTA neurons receive monosynaptic input from the vlPAG, and cranial nociceptive input increases Fos expression in VTA-projecting vlPAG neurons. Activation of PAG inputs to the VTA induces avoidance behavior, while inactivation of these projections induces a place preference only in animals with headache. This work identifies a distinct pathway that mediates cranial nociceptive aversiveness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.