ArticleAnnals of neurology2019
Neuronal Circuit Activity during Neonatal Hypoxic-Ischemic Seizures in Mice.
Article in Annals of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 31 citations in OpenAlex.
- Persistent sensory processing and behavioral atypicalities in a mouse model of neonatal encephalopathy.bioRxiv : the preprint server for biology · 2026Article
- Article
- Lactate receptor HCAR1 in neonatal hypoxic-ischemic seizures.Epilepsia · 2026Article
- Article
- Dual-modal metabolic analysis reveals hypothermia-reversible uncoupling of oxidative phosphorylation in neonatal brain hypoxia-ischemia.bioRxiv : the preprint server for biology · 2025Article
- Low-frequency transcranial magnetic stimulation offers both immediate and delayed neuroprotection in neonatal hypoxia-ischemia model.bioRxiv : the preprint server for biology · 2025Article
- Preoptic area influences sleep-related seizures in a genetic epilepsy mouse model.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Abnormal Local Cortical Functional Connectivity due to Interneuron Dysmaturation after Neonatal Intermittent Hypoxia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Article
- Bone marrow mesenchymal stem cells alleviate neurological dysfunction by reducing autophagy damage via downregulation of SYNPO2 in neonatal hypoxic-ischemic encephalopathy rats.Cell death & disease · 2025Article
- Ongoing loss of viable neurons for weeks after mild hypoxia-ischaemia.Brain communications · 2025Article
- Motor Learning Deficits in a Neonatal Mouse Model of Hypoxic-Ischemic Injury.Children (Basel, Switzerland) · 2024Article
- Article
- Glycolytic lactate production supports status epilepticus in experimental animals.Annals of clinical and translational neurology · 2023Article
- Consequences of oxygen deprivation on myelination and sex-dependent alterations.Molecular and cellular neurosciences · 2023Review
- Preterm birth accelerates the maturation of spontaneous and resting activity in the visual cortex.bioRxiv : the preprint server for biology · 2023Article
- Intermittent hypoxia: linkage between OSAS and epilepsy.Frontiers in pharmacology · 2023Review
- Preterm birth accelerates the maturation of spontaneous and resting activity in the visual cortex.Frontiers in integrative neuroscience · 2023Article
- Cortical pain induced by optogenetic cortical spreading depression: from whole brain activity mapping.Molecular brain · 2022Article
- Functional neuropathology of neonatal hypoxia-ischemia by single-mouse longitudinal electroencephalography.Epilepsia · 2022Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo identify circuits active during neonatal hypoxic-ischemic (HI) seizures and seizure propagation using electroencephalography (EEG), behavior, and whole-brain neuronal activity mapping.
methodsMice were exposed to HI on postnatal day 10 using unilateral carotid ligation and global hypoxia. EEG and video were recorded for the duration of the experiment. Using immediate early gene reporter mice, active cells expressing cfos were permanently tagged with reporter protein tdTomato during a 90-minute window. After 1 week, allowing maximal expression of the reporter protein, whole brains were processed, lipid cleared, and imaged with confocal microscopy. Whole-brain reconstruction and analysis of active neurons (colocalized tdTomato/NeuN) were performed.
resultsHI resulted in seizure behaviors that were bilateral or unilateral tonic-clonic and nonconvulsive in this model. Mice exhibited characteristic EEG background patterns such as burst suppression and suppression. Neuronal activity mapping revealed bilateral motor cortex and unilateral, ischemic somatosensory cortex, lateral thalamus, and hippocampal circuit activation. Immunohistochemical analysis revealed regional differences in myelination, which coincide with these activity patterns. Astrocytes and blood vessel endothelial cells also expressed cfos during HI.
interpretationUsing a combination of EEG, seizure semiology analysis, and whole-brain neuronal activity mapping, we suggest that this rodent model of neonatal HI results in EEG patterns similar to those observed in human neonates. Activation patterns revealed in this study help explain complex seizure behaviors and EEG patterns observed in neonatal HI injury. This pattern may be, in part, secondary to regional differences in development in the neonatal brain. ANN NEUROL 2019;86:927-938.
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