Evidence map›Paper›PMID 31509480›Full record

ArticleMolecular biology of the cell2019

Inhibition of spindle extension through the yeast S phase checkpoint is coupled to replication fork stability and the integrity of centromeric DNA.

Jeff Julius, Jie Peng, Andrew McCulley, Chris Caridi, Remigiusz Arnak, Colby See, Constance I Nugent, Wenyi Feng, Jeff Bachant

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology of the cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. The yeast Dbf4 ZnCurrent genetics · 2022
    Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jeff JuliusDepartment of Molecular Cell Systems Biology, University of California, Riverside, Riverside, CA 92521.
Jie PengDepartment of Biochemistry and Molecular Biology, State University of New York Upstate Medical University, Syracuse, NY 13210.
Andrew McCulleyDepartment of Biochemistry and Molecular Biology, State University of New York Upstate Medical University, Syracuse, NY 13210.
Chris CaridiDepartment of Molecular Cell Systems Biology, University of California, Riverside, Riverside, CA 92521.
Remigiusz ArnakDepartment of Biochemistry and Molecular Biology, State University of New York Upstate Medical University, Syracuse, NY 13210.
Colby SeeDepartment of Molecular Cell Systems Biology, University of California, Riverside, Riverside, CA 92521.
Constance I NugentDepartment of Molecular Cell Systems Biology, University of California, Riverside, Riverside, CA 92521.
Wenyi FengDepartment of Biochemistry and Molecular Biology, State University of New York Upstate Medical University, Syracuse, NY 13210.
Jeff BachantDepartment of Molecular Cell Systems Biology, University of California, Riverside, Riverside, CA 92521.
University of California, Riverside · USSUNY Upstate Medical University · US

Funding

Mechanisms of replication stress-induced chromosome fragilityR01GM118799 · NIGMS · UPSTATE MEDICAL UNIVERSITY · PI FENG, WENYI · 2016 to 2020
$1.6M
NIGMS NIH HHS R01 GM118799
6 · The paper itself

Abstract

Budding yeast treated with hydroxyurea (HU) activate the S phase checkpoint kinase Rad53, which prevents DNA replication forks from undergoing aberrant structural transitions and nuclease processing. Rad53 is also required to prevent premature extension of the mitotic spindle that assembles during a HU-extended S phase. Here we present evidence that checkpoint restraint of spindle extension is directly coupled to Rad53 control of replication fork stability. In budding yeast, centromeres are flanked by replication origins that fire in early S phase. Mutations affecting the Zn

Indexed as

Caenorhabditis elegans ProteinsCell Cycle CheckpointsCell Cycle ProteinsCentromereCheckpoint Kinase 2Chromosome SegregationChromosome StructuresDNA DamageDNA, FungalDNA ReplicationKinetochoresProtein Serine-Threonine KinasesReplication OriginSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsS PhaseCaenorhabditis elegans ProteinsCell Cycle ProteinsCheckpoint Kinase 2Dbf4 protein, S cerevisiaeDNA, FungalProtein Serine-Threonine KinasesRad53 protein kinase, C elegansSaccharomyces cerevisiae Proteins

Identifiers

PMID31509480
PMCPMC6789157
OpenAlexW2972542250

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.