ArticleJournal of neurophysiology2019
Voluntary and tremorogenic inputs to motor neuron pools of agonist/antagonist muscles in essential tremor patients.
Article in Journal of neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 33 citations in OpenAlex.
- Essential Tremor Suppression with a Novel Anti-Tremor Orthosis: A Randomized Crossover Trial.Movement disorders : official journal of the Movement Disorder Society · 2025Trial
- Defining the Rhythm: Developing a New Method to Describe Tremor and Myoclonus.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Ultrasound Imaging Triggered Tremor Suppression With Personalized Afferent Stimulation Frequency.IEEE transactions on bio-medical engineering · 2025Article
- Potential of Individual Upper-Limb Muscles to Contribute to Postural Tremor: Simulations From Neural Drive to Joint Rotation.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025Article
- Hand and distal joint tremor are most coherent with the activity of elbow flexors and wrist extensors in persons with essential tremor.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Towards Ultrasound Imaging-based Closed-loop Peripheral Nerve Stimulation for Tremor Suppression.Current opinion in biomedical engineering · 2023Article
- Decoding firings of a large population of human motor units from high-density surface electromyogram in response to transcranial magnetic stimulation.The Journal of physiology · 2023Article
- Essential Tremor accentuates the pattern of tremor-band coherence between upper-limb muscles.Journal of neurophysiology · 2023Article
- Classification of Kinematic and Electromyographic Signals Associated with Pathological Tremor Using Machine and Deep Learning.Entropy (Basel, Switzerland) · 2023Article
- Distribution of tremorogenic activity among the major superficial muscles of the upper limb in persons with Essential tremor.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2022Article
- Non-invasive electrical stimulation of peripheral nerves for the management of tremor.Journal of the neurological sciences · 2022Review
- Peripheral electrical stimulation to reduce pathological tremor: a review.Journal of neuroengineering and rehabilitation · 2021Review
- Wearable Peripheral Electrical Stimulation Devices for the Reduction of Essential Tremor: A Review.IEEE access : practical innovations, open solutions · 2021Article
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Authors and funding
7 authors at 5 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pathological tremor is an oscillation of body parts at 3-10 Hz, determined by the output of spinal motor neurons (MNs), which receive synaptic inputs from supraspinal centers and muscle afferents. The behavior of spinal MNs during tremor is not well understood, especially in relation to the activation of the multiple muscles involved. Recent studies on patients with essential tremor have shown that antagonist MN pools receive shared input at the tremor frequency. In this study, we investigated the synaptic inputs related to tremor and voluntary movement, and their coordination across antagonist muscles. We analyzed the spike trains of motor units (MUs) identified from high-density surface electromyography from the forearm extensor and flexor muscles in 15 patients with essential tremor during postural tremor. The shared synaptic input was quantified by coherence and phase difference analysis of the spike trains. All pairs of spike trains in each muscle showed coherence peaks at the voluntary drive frequency (1-3 Hz, 0.2 ± 0.2, mean ± SD) and tremor frequency (3-10 Hz, 0.6 ± 0.3) and were synchronized with small phase differences (3.3 ± 25.2° and 3.9 ± 22.0° for the voluntary drive and tremor frequencies, respectively). The coherence between MN spike trains of antagonist muscle groups at the tremor frequency was significantly smaller than intramuscular coherence. We predominantly observed in-phase activation of MUs between agonist/antagonist muscles at the voluntary frequency band (0.6 ± 48.8°) and out-of-phase activation at the tremor frequency band (126.9 ± 75.6°). Thus MNs innervating agonist/antagonist muscles concurrently receive synaptic inputs with different phase shifts in the voluntary and tremor frequency bands.
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