ArticleOmics : a journal of integrative biology2019
Cost-Effectiveness Analysis of a Procalcitonin-Guided Decision Algorithm for Antibiotic Stewardship Using Real-World U.S. Hospital Data.
Article in Omics : a journal of integrative biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Economic Evaluation of Interventions to Reduce Antimicrobial Resistance: A Systematic Literature Review of Methods.PharmacoEconomics · 2025Pooled it
- Costs-effectiveness and cost components of pharmaceutical and non-pharmaceutical interventions affecting antibiotic resistance outcomes in hospital patients: a systematic literature review.BMJ global health · 2024Pooled it
- A systematic literature review of economic evaluation studies of interventions impacting antimicrobial resistance.Antimicrobial resistance and infection control · 2023Pooled it
- Role of Artificial Intelligence Applications in Real-Life Clinical Practice: Systematic Review.Journal of medical Internet research · 2021Pooled it
- The Role and Importance of Procalcitonin (PCT) Testing in Rational Antibiotic Prescribing and Antibiotic Stewardship Programs.Immunity, inflammation and disease · 2026Review
- Patient Benefits in the Context of Sepsis-Related AI-Based Clinical Decision Support Systems: Scoping Review.Journal of medical Internet research · 2026Article
- Compliance of procalcitonin-guided antibiotic therapy in adult infectious patients in China: a multicenter real-world retrospective study.Frontiers in medicine · 2026Article
- Harnessing artificial intelligence for enhanced veterinary diagnostics: A look to quality assurance, Part I Model development.Veterinary clinical pathology · 2025Review
- Antimicrobial stewardship reduces antibiotic use density and cost in a Chinese tertiary hospital.Scientific reports · 2025Article
- Electronic Clinical Decision Support Tools to Manage Patients with Lower Respiratory Tract Infection: Clinicians' Perspectives in Sri Lanka.The American journal of tropical medicine and hygiene · 2025Article
- Artificial intelligence in drug resistance management.3 Biotech · 2025Review
- Antimicrobial resistance at a turning point: microbial drivers, one health, and global futures.Frontiers in microbiology · 2025Review
- Cost-effectiveness of Procalcitonin (PCT) guidance for antibiotics management of adult sepsis patients in the Egyptian context.BMC health services research · 2024Article
- Inflammatory biomarkers as predictors of systemic vs isolated pocket infection in patients undergoing transvenous lead extraction.Heart rhythm O2 · 2024Article
- Micromotor-based dual aptassay for early cost-effective diagnosis of neonatal sepsis.Mikrochimica acta · 2024Article
- Research agenda for using artificial intelligence in health governance: interpretive scoping review and framework.BioData mining · 2023Article
- A real-world cost-effectiveness study of vancomycin versus linezolid for the treatment of late-onset neonatal sepsis in the NICU in China.BMC health services research · 2023Article
- Article
- Guidelines for the Use of Procalcitonin for Rational Use of Antibiotics.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2022Article
- Artificial Intelligence in Biological Sciences.Life (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Medical decision-making is revolutionizing with the introduction of artificial intelligence and machine learning. Yet, traditional algorithms using biomarkers to optimize drug treatment continue to be important and necessary. In this context, early diagnosis and rational antimicrobial therapy of sepsis and lower respiratory tract infections (LRTI) are vital to prevent morbidity and mortality. In this study we report an original cost-effectiveness analysis (CEA) of using a procalcitonin (PCT)-based decision algorithm to guide antibiotic prescription for hospitalized sepsis and LRTI patients versus standard care. We conducted a CEA using a decision-tree model before and after the implementation of PCT-guided antibiotic stewardship (ABS) using real-world U.S. hospital-specific data. The CEA included societal and hospital perspectives with the time horizon covering the length of hospital stay. The main outcomes were average total costs per patient, and numbers of patients with
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.