Evidence map›Paper›PMID 31509011›Full record

ArticleAmerican journal of physiology. Renal physiology2019

In utero exposure to maternal diabetes impairs nephron progenitor differentiation.

Débora M Cerqueira, Shelby L Hemker, Andrew J Bodnar, Daniella M Ortiz, Favour O Oladipupo, Elina Mukherjee, Zhenwei Gong, Corynn Appolonia, Radhika Muzumdar, Sunder Sims-Lucas and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Débora M CerqueiraDivision of Nephrology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Shelby L HemkerDivision of Nephrology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Andrew J BodnarDivision of Nephrology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Daniella M OrtizDivision of Nephrology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Favour O OladipupoDivision of Nephrology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Elina MukherjeeDivision of Nephrology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Zhenwei GongRangos Research Center, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
Corynn AppoloniaDivision of Nephrology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Radhika MuzumdarRangos Research Center, University of Pittsburgh Medical Center Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania.
Sunder Sims-LucasDivision of Nephrology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Jacqueline HoDivision of Nephrology, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.ORCID 0000-0001-7115-1381
University of Pittsburgh · US

Funding

Coordinating and Bioinformatics Unit for the MMPC/DiaCompU24DK076169 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2006 to 2018
$42.4M
Single-Cell Epigenomics, Transcriptomics, and Bioinformatics CoreP50DK096373 · NIDDK · UNIVERSITY OF VIRGINIA · PI Silvia Medrano · 2012 to 2026
$13.8M
Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4M
Coordinating Unit for DiaCompU24DK115255 · NIDDK · AUGUSTA UNIVERSITY · PI MCINDOE, RICHARD A. · 2017 to 2020
$11.6M
Renal and Epithelial Biology Training ProgramT32DK061296 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2002 to 2022
$3.1M
The Role of miR-17~92 in Nephron ProgenitorsR01DK103776 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HO, JACQUELINE · 2014 to 2018
$1.7M
Renal Stroma Derived Endothelial Precursors are Critical for Renal DevelopmentK01DK096996 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SIMS-LUCAS, SUNDER · 2013 to 2017
$557k
Kidney derived endothelial progenitors play a critical role during kidney injuryR03DK110503 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SIMS-LUCAS, SUNDER · 2017 to 2018
$156k
NIDDK NIH HHS K01 DK096996NIDDK NIH HHS P30 DK079307NIDDK NIH HHS P50 DK096373NIDDK NIH HHS R01 DK103776NIDDK NIH HHS R03 DK110503NIDDK NIH HHS T32 DK061296NIDDK NIH HHS U24 DK076169NIDDK NIH HHS U24 DK115255
6 · The paper itself

Abstract

The incidence of diabetes mellitus has significantly increased among women of childbearing age, and it has been shown that prenatal exposure to maternal diabetes increases the risk of associated congenital anomalies of the kidney. Congenital anomalies of the kidney are among the leading causes of chronic kidney disease in children. To better understand the effect of maternal diabetes on kidney development, we analyzed wild-type offspring (DM_Exp) of diabetic

Indexed as

Diabetes, GestationalAnimalsAnimals, NewbornCell DifferentiationFemaleGenetic Predisposition to DiseaseGenotypeInsulinInsulin-Secreting CellsMaleMiceMutationNephronsPregnancyStem CellsTranscription FactorsInsulinTranscription Factorsdiabeteskidney developmentnephron formationnephron progenitor

Identifiers

PMID31509011
PMCPMC6879946
OpenAlexW2972419827

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.