SynthesisCartilage2021
Systematic Review and Meta-Analysis of the Clinical Evidence on the Use of Autologous Matrix-Induced Chondrogenesis in the Knee.
Synthesis in Cartilage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Autologous matrix-induced chondrogenesis is effective for focal chondral defects of the knee.Scientific reports · 2022Pooled it
- A randomized controlled trial demonstrating sustained benefit of autologous matrix-induced chondrogenesis (AMICEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Trial
- The Use of a Human Acellular Dermal Matrix (hADM) Transplant in Stage 4 Osteochondrosis Dissecans: A Retrospective Proof of Concept.Journal of clinical medicine · 2026Article
- Treatment Options for Focal Cartilage Lesions of the Knee.Deutsches Arzteblatt international · 2026Review
- Minced cartilage implantation for cartilage regeneration: a survey of current clinical practices.Archives of orthopaedic and trauma surgery · 2026Article
- Outcomes of Restorative Treatment for Isolated Patellar Cartilage Lesions: A Systematic Review and Meta-analysis.Orthopaedic journal of sports medicine · 2026Review
- Starch-Gelatin-Based Scaffolds for Cartilage Defect Repair: An in vitro Study Supporting Its Potential Clinical Use.Cartilage · 2025Article
- Outcomes Following the Arthroscopic Chondro-Gide Repair of Osteochondral Defects of the Talus.Cureus · 2025Article
- AMIC achieves sustained clinical improvement in isolated patellar cartilage defects over 5 years, correlating with MRI.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025Article
- The collagen-augmented chondrogenesis technique demonstrates superior cartilage repair compared to microfracture for cartilage defects of the knee joint, regardless of age.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2025Article
- Tissue Engineered Cartilage Repair Using Small-Incision Implantation of Decalcified Corticocancellous Bone Scaffold.Arthroscopy techniques · 2025Article
- LIPO-AMIC Technique Description: Autologous Matrix Induced-Chondrogenesis With Microfragmented Adipose Tissue Graft.Arthroscopy techniques · 2025Article
- Charting a quarter-century of commercial cartilage regeneration products.Journal of orthopaedic translation · 2025Review
- Absorbable Nail Fixation of Biologic Membrane for Treatment of Cartilage Defects by Matrix-Induced Autologous Chondrocyte Implantation.Arthroscopy techniques · 2024Article
- One-stage cartilage repair using the autologous matrix-induced chondrogenesis combined with simultaneous use of autologous adipose tissue graft and adipose tissue mesenchymal cells technique: clinical results and magnetic resonance imaging evaluation at five-year follow-up.International orthopaedics · 2024Article
- Microfracture- and Xeno-Matrix-Induced Chondrogenesis for Treatment of Focal Traumatic Cartilage Defects of the Knee: Age-Based Mid-Term Results.Healthcare (Basel, Switzerland) · 2023Article
- Single-Stage Arthroscopic Cartilage Repair With Chondrectomy and Implantation of a Templated Membrane Collagen Scaffold With Bone Marrow Aspirate Concentrate Augmentation (AMIC Plus).Arthroscopy techniques · 2023Article
- Treatment of knee cartilage by cultured stem cells and three dimensional scaffold: a phase I/IIa clinical trial.International orthopaedics · 2023Article
- Failure of cartilage regeneration: emerging hypotheses and related therapeutic strategies.Nature reviews. Rheumatology · 2023Review
- Scaffolds for Cartilage Tissue Engineering from a Blend of Polyethersulfone and Polyurethane Polymers.Molecules (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveA systematic review and meta-analysis of Autologous Matrix-Induced Chondrogenesis (AMIC®) outcomes for grade III/IV chondral and osteochondral lesions of the knee treated with Chondro-Gide®.
designStudies with a minimum follow-up of 1 year providing clinical results of AMIC repair in the knee were included based on PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). Methodological quality was assessed by the modified Coleman Methodology Score (mCMS). The meta-analysis was comparing pain VAS (Visual Analog Scale), Lysholm score, and IKDC score (International Knee Documentation Committee) between baseline and follow-up after 1 or 2 years and after >3 years.
resultsTwelve studies (375 patients) were included. The mCMS demonstrated a suboptimal study design (ranking between 52 and 80). The mean age was 36.2 years (14-70 years). The mean defect size was 4.24 cm
conclusionsThe AMIC procedure significantly improved the clinical status and functional scoring versus preoperative values. Evidence was obtained in a non-selected patient population, corresponding to real-life treatment of knee chondral and osteochondral defects. The evidence is sufficient to recommend AMIC in this indication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.