Evidence map›Paper›PMID 31508904›Full record

ArticleAnnals of clinical and translational neurology2019

Responsive neurostimulation targeting anterior thalamic nucleus in generalized epilepsy.

Aline Herlopian, Sydney S Cash, Emad M Eskandar, Tara Jennings, Andrew J Cole

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of clinical and translational neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. The thalamus: Structure, function, and neurotherapeutics.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Review
  3. Review
  4. Characteristics of ictal thalamic EEG in pediatric-onset neocortical focal epilepsy.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023
    Article
  5. Characteristics of ictal thalamic EEG in pediatric-onset neocortical focal epilepsy.medRxiv : the preprint server for health sciences · 2023
    Article
  6. Article
  7. Article
  8. Towards network-guided neuromodulation for epilepsy.Brain : a journal of neurology · 2022
    Review
  9. Article
  10. Review
  11. Article
  12. Emerging Trends in Neuromodulation for Treatment of Drug-Resistant Epilepsy.Frontiers in pain research (Lausanne, Switzerland) · 2022
    Review
  13. Review
  14. Article
  15. Article
  16. Precision mapping of the epileptogenic network with low- and high-frequency stimulation of anterior nucleus of thalamus.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2020
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Aline HerlopianMGH Epilepsy Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, ACC 739L, Boston, Massachusetts, 02114.ORCID 0000-0002-0189-7011
Sydney S CashMGH Epilepsy Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, ACC 739L, Boston, Massachusetts, 02114.
Emad M EskandarDepartment of Neurosurgery, Massachusetts General Hospital, 55 Fruit St, Wang 7, Boston, Massachusetts, 02114.
Tara JenningsMGH Epilepsy Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, ACC 739L, Boston, Massachusetts, 02114.
Andrew J ColeMGH Epilepsy Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, ACC 739L, Boston, Massachusetts, 02114.
Harvard University · USMontefiore Medical Center · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

Responsive neurostimulation (RNS) has emerged as an adjunctive treatment modality for patients with intractable focal epilepsy who are not surgical candidates or have more than one ictal onset focus. We report a 34-year-old patient with intractable, childhood-onset, genetic generalized epilepsy (GGE) with tonic, atonic, myoclonic and absence seizures treated with RNS. Strip electrodes over the right posterior frontal cortex and depth electrodes placed in the right anterior nucleus were used for event detection and responsive stimulation. Two-year follow-up revealed 90-95% clinical seizure reduction. This case suggests that refractory GGE may be effectively treated with RNS targeting thalamocortical networks.

Indexed as

Anterior Thalamic NucleiFrontal LobeAdultDrug Resistant EpilepsyElectric Stimulation TherapyEpilepsy, GeneralizedHumansImplantable NeurostimulatorsMale

Identifiers

PMID31508904
PMCPMC6801174
OpenAlexW2972781749

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.