ReviewJournal of orthopaedic research : official publication of the Orthopaedic Research Society2020
Murine Axial Compression Tibial Loading Model to Study Bone Mechanobiology: Implementing the Model and Reporting Results.
Review in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed.
- Bone anabolic effects of tibial loading in combination with dual sclerostin and Dkk1 antibodies in aged mice.JBMR plus · 2026Article
- Joint damage is more severe following a single bout than multiple bouts of high magnitude loading in mice.Osteoarthritis and cartilage · 2026Article
- Quantifying the local strain energy density distribution in the mouse tibia: the critical role of the loading direction.Biomechanics and modeling in mechanobiology · 2025Article
- The skeletal transcriptional response to mechanical load varies with age and tissue compartment in female mice.JBMR plus · 2025Article
- Estrogen loss activates memory T-cells to compromise bone integrity through distinct cortical compartments in mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Article
- Cartilage repair: unleashing PRP's potential in organoid models.Cytotechnology · 2025Review
- Skeletal impacts of dual in vivo compressive axial tibial and ulnar loading in mice.Journal of the mechanical behavior of biomedical materials · 2025Article
- Toward a clear relationship between mechanical signals and bone adaptation.Mechanobiology in medicine · 2025Review
- Spatial transcriptomics in bone mechanomics: Exploring the mechanoregulation of fracture healing in the era of spatial omics.Science advances · 2025Article
- Tibial Biomechanics and Adaptive Response to Mechanical Stimuli in the Green Iguana.Integrative organismal biology (Oxford, England) · 2025Article
- Activation of connexin hemichannels enhances mechanosensitivity and anabolism in disused and aged bone.JCI insight · 2024Article
- The Lacunocanalicular Network is Denser in C57BL/6 Compared to BALB/c Mice.Calcified tissue international · 2024Article
- Prkd1 regulates the formation and repair of plasma membrane disruptions (PMD) in osteocytes.Bone · 2024Article
- Tissue material properties, whole-bone morphology and mechanical behavior in theMatrix biology plus · 2024Article
- Article
- PTH treatment before cyclic joint loading improves cartilage health and attenuates load-induced osteoarthritis development in mice.Science advances · 2024Article
- The loading direction dramatically affects the mechanical properties of the mouse tibia.Frontiers in bioengineering and biotechnology · 2024Article
- Spatial variations in the osteocyte lacuno-canalicular network density and analysis of the connectomic parameters.PloS one · 2024Article
- L-BAIBA Synergizes with Sub-Optimal Mechanical Loading to Promote New Bone Formation.JBMR plus · 2023Article
- Osteocyte Estrogen Receptor β (Ot-ERβ) Regulates Bone Turnover and Skeletal Adaptive Response to Mechanical Loading Differently in Male and Female Growing and Adult Mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
In vivo, tibial loading in mice is increasingly used to study bone adaptation and mechanotransduction. To achieve standardized and defined experimental conditions, loading parameters and animal-related factors must be considered when performing in vivo loading studies. In this review, we discuss these loading and animal-related experimental conditions, present methods to assess bone adaptation, and suggest reporting guidelines. This review originated from presentations by each of the authors at the workshop "Developing Best Practices for Mouse Models of In Vivo Loading" during the Preclinical Models Section at the Orthopaedic Research Society Annual Meeting, San Diego, CA, March 2017. Following the meeting, the authors engaged in detailed discussions with consideration of relevant literature. The guidelines and recommendations in this review are provided to help researchers perform in vivo loading experiments in mice, and thus further our knowledge of bone adaptation and the mechanisms involved in mechanotransduction. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 38:233-252, 2020.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.