Evidence map›Paper›PMID 31508644›Full record

ArticleLab on a chip2019

Contactless, programmable acoustofluidic manipulation of objects on water.

Peiran Zhang, Chuyi Chen, Feng Guo, Julien Philippe, Yuyang Gu, Zhenhua Tian, Hunter Bachman, Liqiang Ren, Shujie Yang, Zhanwei Zhong and 4 more

Abstract read
In one paragraph

Article in Lab on a chip, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Programmable Droplet Microfluidics Based on Machine Learning and Acoustic Manipulation.Langmuir : the ACS journal of surfaces and colloids · 2022
    Article
  11. Article
  12. Article
  13. Review
  14. Hardware Design and Fault-Tolerant Synthesis for Digital Acoustofluidic Biochips.IEEE transactions on biomedical circuits and systems · 2020
    Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Peiran ZhangDepartment of Mechanical Engineering and Material Science, Duke University, NC 27708, USA. tony.huang@duke.edu.
Chuyi Chen
Feng Guo
Julien Philippe
Yuyang Gu
Zhenhua Tian
Hunter Bachman
Liqiang Ren
Shujie Yang
Zhanwei Zhong
Po-Hsun Huang
Nicholas Katsanis
Krishnendu Chakrabarty
Tony Jun Huang

Funding

Enabling Efficient, Fast, Biocompatible Exosome Separation via AcoustofluidicsR01GM132603 · NIGMS · DUKE UNIVERSITY · PI HUANG, TONY JUN · 2019 to 2022
$1.7M
Determining treatment sensitivity in B cell lymphoma by novel microfluidics-based NK cell immunogenicity platformR33CA223908 · NCI · NORTHEASTERN UNIVERSITY · PI EVENS, ANDREW M, HUANG, TONY JUN · 2018 to 2020
$1.2M
An integrated acoustofluidic droplet-sorting platform for classification of lymphocyte activity and functional phenotyping at single cell levelR01GM127714 · NIGMS · NORTHEASTERN UNIVERSITY · PI KONRY, TANIA TALI · 2018 to 2021
$1.2M
NCI NIH HHS R33 CA223908NIGMS NIH HHS R01 GM127714NIGMS NIH HHS R01 GM132603
6 · The paper itself

Abstract

Contact-free manipulation of small objects (e.g., cells, tissues, and droplets) using acoustic waves eliminates physical contact with structures and undesired surface adsorption. Pioneering acoustic-based, contact-free manipulation techniques (e.g., acoustic levitation) enable programmable manipulation but are limited by evaporation, bulky transducers, and inefficient acoustic coupling in air. Herein, we report an acoustofluidic mechanism for the contactless manipulation of small objects on water. A hollow-square-shaped interdigital transducer (IDT) is fabricated on lithium niobate (LiNbO3), immersed in water and used as a sound source to generate acoustic waves and as a micropump to pump fluid in the ±x and ±y orthogonal directions. As a result, objects which float adjacent to the excited IDT can be pushed unidirectionally (horizontally) in ±x and ±y following the directed acoustic wave propagation. A fluidic processor was developed by patterning IDT units in a 6-by-6 array. We demonstrate contactless, programmable manipulation on water of oil droplets and zebrafish larvae. This acoustofluidic-based manipulation opens avenues for the contactless, programmable processing of materials and small biosamples.

Indexed as

SoundAnimalsLarvaMicrofluidicsNiobiumOxidesTransducersWaterZebrafishlithium niobateNiobiumOxidesWater

Identifiers

PMID31508644
PMCPMC6934417

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.